Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)

Detalhes bibliográficos
Autor(a) principal: KIM,Hyun-Hee
Data de Publicação: 2022
Outros Autores: LEE,Songmi, Kim,Seo-Hee, YIM,Soon-Ho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767
Resumo: Abstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii.
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spelling Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)Sambucus williamsii var. coreana Nakai (Caprifoliaceae)anti-cancerTriterpenoidbetulinic acidoleanolic acidursolic acidAbstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.76021info:eu-repo/semantics/openAccessKIM,Hyun-HeeLEE,SongmiKim,Seo-HeeYIM,Soon-Hoeng2022-03-22T00:00:00Zoai:scielo:S0101-20612022000100767Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-03-22T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
title Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
spellingShingle Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
KIM,Hyun-Hee
Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
anti-cancer
Triterpenoid
betulinic acid
oleanolic acid
ursolic acid
title_short Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
title_full Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
title_fullStr Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
title_full_unstemmed Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
title_sort Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
author KIM,Hyun-Hee
author_facet KIM,Hyun-Hee
LEE,Songmi
Kim,Seo-Hee
YIM,Soon-Ho
author_role author
author2 LEE,Songmi
Kim,Seo-Hee
YIM,Soon-Ho
author2_role author
author
author
dc.contributor.author.fl_str_mv KIM,Hyun-Hee
LEE,Songmi
Kim,Seo-Hee
YIM,Soon-Ho
dc.subject.por.fl_str_mv Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
anti-cancer
Triterpenoid
betulinic acid
oleanolic acid
ursolic acid
topic Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
anti-cancer
Triterpenoid
betulinic acid
oleanolic acid
ursolic acid
description Abstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.76021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.42 2022
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
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reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
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