Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767 |
Resumo: | Abstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii. |
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Food Science and Technology (Campinas) |
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Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae)Sambucus williamsii var. coreana Nakai (Caprifoliaceae)anti-cancerTriterpenoidbetulinic acidoleanolic acidursolic acidAbstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.76021info:eu-repo/semantics/openAccessKIM,Hyun-HeeLEE,SongmiKim,Seo-HeeYIM,Soon-Hoeng2022-03-22T00:00:00Zoai:scielo:S0101-20612022000100767Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-03-22T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
title |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
spellingShingle |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) KIM,Hyun-Hee Sambucus williamsii var. coreana Nakai (Caprifoliaceae) anti-cancer Triterpenoid betulinic acid oleanolic acid ursolic acid |
title_short |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
title_full |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
title_fullStr |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
title_full_unstemmed |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
title_sort |
Triterpenoid constituents and Their Anti-cancer activity from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae) |
author |
KIM,Hyun-Hee |
author_facet |
KIM,Hyun-Hee LEE,Songmi Kim,Seo-Hee YIM,Soon-Ho |
author_role |
author |
author2 |
LEE,Songmi Kim,Seo-Hee YIM,Soon-Ho |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
KIM,Hyun-Hee LEE,Songmi Kim,Seo-Hee YIM,Soon-Ho |
dc.subject.por.fl_str_mv |
Sambucus williamsii var. coreana Nakai (Caprifoliaceae) anti-cancer Triterpenoid betulinic acid oleanolic acid ursolic acid |
topic |
Sambucus williamsii var. coreana Nakai (Caprifoliaceae) anti-cancer Triterpenoid betulinic acid oleanolic acid ursolic acid |
description |
Abstract This study aims at characterization of the anti-cancer active compounds separated from stems and branches of Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation of ethanol extracts from the S. williamsii was isolated of three triterpenoid compounds. S. williamsii fractions showed superior growth inhibitory activity against three cancer cells (HCT116, A549 and MDA-MB231). Active fraction was isolated and analyzed and led to the identification of three active triterpenoid compounds using HPLC, NMR, and LC-MS spectrometer, their structures were established as betulinic acid (1), oleanolic acid (2) and ursolic acid (3). The results of this study performed with S. williamsii will be helpful to develop new and efficient anti-cancer agents. Also, this research was supported the previous separations and isolations studies on active ingredients of S. williamsii. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100767 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.76021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.42 2022 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
_version_ |
1752126332862464000 |