Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells

Detalhes bibliográficos
Autor(a) principal: ZHAO,Yinjuan
Data de Publicação: 2021
Outros Autores: CHENG,Qi, SHEN,Zizhu, FAN,Ben, XU,Yan, CAO,Yuting, PENG,Fanxi, ZHAO,Jingkai, XUE,Bin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000500189
Resumo: Abstract Prodigiosin, a secondary metabolite extracted from Serratia marcescens (S. marcescens), could induce apoptosis in various cancer cells, with however low toxicity on normal cells. The red pigment was extracted from a strain S. marcescens NJZT-1 isolated from soil, which had antibacterial activity. Spectral analyses (LC-ESI-MS, UV-VIS spectrophotometry, infrared spectra and HPLC) and TLC indicated the presence of prodigiosin in the extracellular bacterial culture extracts. The red pigment effectively killed the TSC2-null cells, whose mutation resulted in the progressive and systemic disease LAM. Our findings provide interesting evidence and important basis for the development of new therapeutic compounds with high potential effects against TSC2-null cells.
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spelling Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cellsnatural productsprodigiosinSerratia marcescens (S. marcescens) NJZT-1anticancer activityLAMTSC2-null cellsAbstract Prodigiosin, a secondary metabolite extracted from Serratia marcescens (S. marcescens), could induce apoptosis in various cancer cells, with however low toxicity on normal cells. The red pigment was extracted from a strain S. marcescens NJZT-1 isolated from soil, which had antibacterial activity. Spectral analyses (LC-ESI-MS, UV-VIS spectrophotometry, infrared spectra and HPLC) and TLC indicated the presence of prodigiosin in the extracellular bacterial culture extracts. The red pigment effectively killed the TSC2-null cells, whose mutation resulted in the progressive and systemic disease LAM. Our findings provide interesting evidence and important basis for the development of new therapeutic compounds with high potential effects against TSC2-null cells.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000500189Food Science and Technology v.41 suppl.1 2021reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.35719info:eu-repo/semantics/openAccessZHAO,YinjuanCHENG,QiSHEN,ZizhuFAN,BenXU,YanCAO,YutingPENG,FanxiZHAO,JingkaiXUE,Bineng2021-06-11T00:00:00Zoai:scielo:S0101-20612021000500189Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2021-06-11T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
title Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
spellingShingle Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
ZHAO,Yinjuan
natural products
prodigiosin
Serratia marcescens (S. marcescens) NJZT-1
anticancer activity
LAMTSC2-null cells
title_short Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
title_full Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
title_fullStr Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
title_full_unstemmed Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
title_sort Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells
author ZHAO,Yinjuan
author_facet ZHAO,Yinjuan
CHENG,Qi
SHEN,Zizhu
FAN,Ben
XU,Yan
CAO,Yuting
PENG,Fanxi
ZHAO,Jingkai
XUE,Bin
author_role author
author2 CHENG,Qi
SHEN,Zizhu
FAN,Ben
XU,Yan
CAO,Yuting
PENG,Fanxi
ZHAO,Jingkai
XUE,Bin
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv ZHAO,Yinjuan
CHENG,Qi
SHEN,Zizhu
FAN,Ben
XU,Yan
CAO,Yuting
PENG,Fanxi
ZHAO,Jingkai
XUE,Bin
dc.subject.por.fl_str_mv natural products
prodigiosin
Serratia marcescens (S. marcescens) NJZT-1
anticancer activity
LAMTSC2-null cells
topic natural products
prodigiosin
Serratia marcescens (S. marcescens) NJZT-1
anticancer activity
LAMTSC2-null cells
description Abstract Prodigiosin, a secondary metabolite extracted from Serratia marcescens (S. marcescens), could induce apoptosis in various cancer cells, with however low toxicity on normal cells. The red pigment was extracted from a strain S. marcescens NJZT-1 isolated from soil, which had antibacterial activity. Spectral analyses (LC-ESI-MS, UV-VIS spectrophotometry, infrared spectra and HPLC) and TLC indicated the presence of prodigiosin in the extracellular bacterial culture extracts. The red pigment effectively killed the TSC2-null cells, whose mutation resulted in the progressive and systemic disease LAM. Our findings provide interesting evidence and important basis for the development of new therapeutic compounds with high potential effects against TSC2-null cells.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000500189
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000500189
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.35719
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.41 suppl.1 2021
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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