Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1

Detalhes bibliográficos
Autor(a) principal: Lastória,Joel Carlos
Data de Publicação: 2014
Outros Autores: Abreu,Marilda Aparecida Milanez Morgado de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200205
Resumo: Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
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spelling Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1ClassificationClinical diagnosisDisease transmission, infectiousEducation, continuingEpidemiologyGenetic phenomenaImmunologic factorsLeprosyMycobacterium lepraeSigns and symptomsLeprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.Sociedade Brasileira de Dermatologia2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200205Anais Brasileiros de Dermatologia v.89 n.2 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20142450info:eu-repo/semantics/openAccessLastória,Joel CarlosAbreu,Marilda Aparecida Milanez Morgado deeng2014-06-11T00:00:00Zoai:scielo:S0365-05962014000200205Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2014-06-11T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
spellingShingle Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
Lastória,Joel Carlos
Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
title_short Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_full Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_fullStr Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_full_unstemmed Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_sort Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
author Lastória,Joel Carlos
author_facet Lastória,Joel Carlos
Abreu,Marilda Aparecida Milanez Morgado de
author_role author
author2 Abreu,Marilda Aparecida Milanez Morgado de
author2_role author
dc.contributor.author.fl_str_mv Lastória,Joel Carlos
Abreu,Marilda Aparecida Milanez Morgado de
dc.subject.por.fl_str_mv Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
topic Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
description Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200205
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200205
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20142450
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.89 n.2 2014
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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