Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1

Detalhes bibliográficos
Autor(a) principal: Lastoria, Joel Carlos [UNESP]
Data de Publicação: 2014
Outros Autores: Abreu, Marilda Aparecida Milanez Morgado De
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20142450
http://hdl.handle.net/11449/109579
Resumo: Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
id UNSP_9b164427b39d22ce174ecaeb46b0e7cf
oai_identifier_str oai:repositorio.unesp.br:11449/109579
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1ClassificationClinical diagnosisDisease transmission, infectiousEducation, continuingEpidemiologyGenetic phenomenaImmunologic factorsLeprosyMycobacterium lepraeSigns and symptomsLeprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de BotucatuUniversidade do Oeste Paulista Hospital Regional de Presidente PrudenteUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de BotucatuSociedade Brasileira de DermatologiaUniversidade Estadual Paulista (Unesp)Universidade do Oeste Paulista (UNOESTE)Lastoria, Joel Carlos [UNESP]Abreu, Marilda Aparecida Milanez Morgado De2014-09-30T18:18:29Z2014-09-30T18:18:29Z2014-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article205-218application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20142450Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 2, p. 205-218, 2014.0365-0596http://hdl.handle.net/11449/10957910.1590/abd1806-4841.20142450S0365-05962014000200205WOS:000335171600001S0365-05962014000200205.pdf9531498781164017SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0.8840,520info:eu-repo/semantics/openAccess2024-08-14T18:45:08Zoai:repositorio.unesp.br:11449/109579Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:45:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
spellingShingle Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
Lastoria, Joel Carlos [UNESP]
Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
title_short Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_full Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_fullStr Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_full_unstemmed Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
title_sort Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
author Lastoria, Joel Carlos [UNESP]
author_facet Lastoria, Joel Carlos [UNESP]
Abreu, Marilda Aparecida Milanez Morgado De
author_role author
author2 Abreu, Marilda Aparecida Milanez Morgado De
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade do Oeste Paulista (UNOESTE)
dc.contributor.author.fl_str_mv Lastoria, Joel Carlos [UNESP]
Abreu, Marilda Aparecida Milanez Morgado De
dc.subject.por.fl_str_mv Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
topic Classification
Clinical diagnosis
Disease transmission, infectious
Education, continuing
Epidemiology
Genetic phenomena
Immunologic factors
Leprosy
Mycobacterium leprae
Signs and symptoms
description Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multibacillary patients. Transmission occurs through inhalation of bacilli present in upper airway secretion. The nasal mucosa is the main entry or exit route of M. leprae. The deeper understanding of the structural and biological characteristics of M. leprae, the sequencing of its genome, along with the advances in understanding the mechanisms of host immune response against the bacilli, dependent on genetic susceptibility, have contributed to the understanding of the pathogenesis, variations in the clinical characteristics, and progression of the disease. This article aims to update dermatologist on epidemiological, clinical, and etiopathogenic leprosy aspects.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-30T18:18:29Z
2014-09-30T18:18:29Z
2014-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20142450
Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 2, p. 205-218, 2014.
0365-0596
http://hdl.handle.net/11449/109579
10.1590/abd1806-4841.20142450
S0365-05962014000200205
WOS:000335171600001
S0365-05962014000200205.pdf
9531498781164017
url http://dx.doi.org/10.1590/abd1806-4841.20142450
http://hdl.handle.net/11449/109579
identifier_str_mv Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 2, p. 205-218, 2014.
0365-0596
10.1590/abd1806-4841.20142450
S0365-05962014000200205
WOS:000335171600001
S0365-05962014000200205.pdf
9531498781164017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0.884
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 205-218
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128100113842176

Registros relacionados