Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation

Detalhes bibliográficos
Autor(a) principal: Pegorare,Ana Beatriz Gomes de Souza
Data de Publicação: 2014
Outros Autores: Gonçalves,Marco Antônio, Suaid,Carla Adelino, Rodrigues Junior,Antonio Antunes, Tucci Jr,Silvio, Suaid,Haylton Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457
Resumo: PURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea.
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spelling Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluationDiabetes MellitusUrinary BladderUrethraUrodynamicsRatsWistarPURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457Acta Cirúrgica Brasileira v.29 n.7 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000700008info:eu-repo/semantics/openAccessPegorare,Ana Beatriz Gomes de SouzaGonçalves,Marco AntônioSuaid,Carla AdelinoRodrigues Junior,Antonio AntunesTucci Jr,SilvioSuaid,Haylton Jorgeeng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000700457Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
title Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
spellingShingle Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
Pegorare,Ana Beatriz Gomes de Souza
Diabetes Mellitus
Urinary Bladder
Urethra
Urodynamics
Rats
Wistar
title_short Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
title_full Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
title_fullStr Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
title_full_unstemmed Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
title_sort Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
author Pegorare,Ana Beatriz Gomes de Souza
author_facet Pegorare,Ana Beatriz Gomes de Souza
Gonçalves,Marco Antônio
Suaid,Carla Adelino
Rodrigues Junior,Antonio Antunes
Tucci Jr,Silvio
Suaid,Haylton Jorge
author_role author
author2 Gonçalves,Marco Antônio
Suaid,Carla Adelino
Rodrigues Junior,Antonio Antunes
Tucci Jr,Silvio
Suaid,Haylton Jorge
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pegorare,Ana Beatriz Gomes de Souza
Gonçalves,Marco Antônio
Suaid,Carla Adelino
Rodrigues Junior,Antonio Antunes
Tucci Jr,Silvio
Suaid,Haylton Jorge
dc.subject.por.fl_str_mv Diabetes Mellitus
Urinary Bladder
Urethra
Urodynamics
Rats
Wistar
topic Diabetes Mellitus
Urinary Bladder
Urethra
Urodynamics
Rats
Wistar
description PURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502014000700008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.29 n.7 2014
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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