Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457 |
Resumo: | PURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea. |
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Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluationDiabetes MellitusUrinary BladderUrethraUrodynamicsRatsWistarPURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457Acta Cirúrgica Brasileira v.29 n.7 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000700008info:eu-repo/semantics/openAccessPegorare,Ana Beatriz Gomes de SouzaGonçalves,Marco AntônioSuaid,Carla AdelinoRodrigues Junior,Antonio AntunesTucci Jr,SilvioSuaid,Haylton Jorgeeng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000700457Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
title |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
spellingShingle |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation Pegorare,Ana Beatriz Gomes de Souza Diabetes Mellitus Urinary Bladder Urethra Urodynamics Rats Wistar |
title_short |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
title_full |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
title_fullStr |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
title_full_unstemmed |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
title_sort |
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation |
author |
Pegorare,Ana Beatriz Gomes de Souza |
author_facet |
Pegorare,Ana Beatriz Gomes de Souza Gonçalves,Marco Antônio Suaid,Carla Adelino Rodrigues Junior,Antonio Antunes Tucci Jr,Silvio Suaid,Haylton Jorge |
author_role |
author |
author2 |
Gonçalves,Marco Antônio Suaid,Carla Adelino Rodrigues Junior,Antonio Antunes Tucci Jr,Silvio Suaid,Haylton Jorge |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pegorare,Ana Beatriz Gomes de Souza Gonçalves,Marco Antônio Suaid,Carla Adelino Rodrigues Junior,Antonio Antunes Tucci Jr,Silvio Suaid,Haylton Jorge |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Urinary Bladder Urethra Urodynamics Rats Wistar |
topic |
Diabetes Mellitus Urinary Bladder Urethra Urodynamics Rats Wistar |
description |
PURPOSE:To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700457 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502014000700008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.7 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442626351104 |