Effect of propranolol on capsular reaction around silicone implants in guinea pigs

Detalhes bibliográficos
Autor(a) principal: Mesquita,Charles Jean Gomes de
Data de Publicação: 2015
Outros Autores: Guimarães,Sérgio Botelho, Leite Filho,José Alberto Dias, Maciel,Felipe Silva, Rocha,José Lima de Carvalho, Leite,José Alberto Dias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100024
Resumo: PURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.METHODS:Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.CONCLUSION:Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
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spelling Effect of propranolol on capsular reaction around silicone implants in guinea pigsSilicone ElastomersImplant Capsular ContractureCollagenPropranololGuinea PigsPURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.METHODS:Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.CONCLUSION:Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100024Acta Cirúrgica Brasileira v.30 n.1 2015reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502015001000004info:eu-repo/semantics/openAccessMesquita,Charles Jean Gomes deGuimarães,Sérgio BotelhoLeite Filho,José Alberto DiasMaciel,Felipe SilvaRocha,José Lima de CarvalhoLeite,José Alberto Diaseng2015-10-08T00:00:00Zoai:scielo:S0102-86502015000100024Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effect of propranolol on capsular reaction around silicone implants in guinea pigs
title Effect of propranolol on capsular reaction around silicone implants in guinea pigs
spellingShingle Effect of propranolol on capsular reaction around silicone implants in guinea pigs
Mesquita,Charles Jean Gomes de
Silicone Elastomers
Implant Capsular Contracture
Collagen
Propranolol
Guinea Pigs
title_short Effect of propranolol on capsular reaction around silicone implants in guinea pigs
title_full Effect of propranolol on capsular reaction around silicone implants in guinea pigs
title_fullStr Effect of propranolol on capsular reaction around silicone implants in guinea pigs
title_full_unstemmed Effect of propranolol on capsular reaction around silicone implants in guinea pigs
title_sort Effect of propranolol on capsular reaction around silicone implants in guinea pigs
author Mesquita,Charles Jean Gomes de
author_facet Mesquita,Charles Jean Gomes de
Guimarães,Sérgio Botelho
Leite Filho,José Alberto Dias
Maciel,Felipe Silva
Rocha,José Lima de Carvalho
Leite,José Alberto Dias
author_role author
author2 Guimarães,Sérgio Botelho
Leite Filho,José Alberto Dias
Maciel,Felipe Silva
Rocha,José Lima de Carvalho
Leite,José Alberto Dias
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mesquita,Charles Jean Gomes de
Guimarães,Sérgio Botelho
Leite Filho,José Alberto Dias
Maciel,Felipe Silva
Rocha,José Lima de Carvalho
Leite,José Alberto Dias
dc.subject.por.fl_str_mv Silicone Elastomers
Implant Capsular Contracture
Collagen
Propranolol
Guinea Pigs
topic Silicone Elastomers
Implant Capsular Contracture
Collagen
Propranolol
Guinea Pigs
description PURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.METHODS:Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.CONCLUSION:Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502015001000004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.30 n.1 2015
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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