Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation

Detalhes bibliográficos
Autor(a) principal: Leite,Fábio Renato Manzolli
Data de Publicação: 2008
Outros Autores: Ramalho,Lizeti Toledo de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000200008
Resumo: Innocuous biocompatible materials have been searched to repair or reconstruct bone defects. Their goal is to restore the function of live or dead tissues. This study compared connective tissue and bone reaction when exposed to demineralized bovine bone matrix and a polyurethane resin derived from castor bean (Ricinus communis). Forty-five rats were assigned to 3 groups of 15 animals (control, bovine bone and polyurethane). A cylindrical defect was created on mandible base and filled with bovine bone matrix and the polyurethane. Control group received no treatment. Analyses were performed after 15, 45 and 60 days (5 animals each). Histological analysis revealed connective tissue tolerance to bovine bone with local inflammatory response similar to that of the control group. After 15 days, all groups demonstrated similar outcomes, with mild inflammatory reaction, probably due to the surgical procedure rather than to the material. In the polymer group, after 60 days, scarce multinucleated cells could still be observed. In general, all groups showed good stability and osteogenic connective tissue with blood vessels into the surgical area. The results suggest biocompatibility of both materials, seen by their integration into rat mandible. Moreover, the polyurethane seems to be an alternative in bone reconstruction and it is an inexhaustible source of biomaterial.
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spelling Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantationBone regenerationRicinus communisBone substitutesInnocuous biocompatible materials have been searched to repair or reconstruct bone defects. Their goal is to restore the function of live or dead tissues. This study compared connective tissue and bone reaction when exposed to demineralized bovine bone matrix and a polyurethane resin derived from castor bean (Ricinus communis). Forty-five rats were assigned to 3 groups of 15 animals (control, bovine bone and polyurethane). A cylindrical defect was created on mandible base and filled with bovine bone matrix and the polyurethane. Control group received no treatment. Analyses were performed after 15, 45 and 60 days (5 animals each). Histological analysis revealed connective tissue tolerance to bovine bone with local inflammatory response similar to that of the control group. After 15 days, all groups demonstrated similar outcomes, with mild inflammatory reaction, probably due to the surgical procedure rather than to the material. In the polymer group, after 60 days, scarce multinucleated cells could still be observed. In general, all groups showed good stability and osteogenic connective tissue with blood vessels into the surgical area. The results suggest biocompatibility of both materials, seen by their integration into rat mandible. Moreover, the polyurethane seems to be an alternative in bone reconstruction and it is an inexhaustible source of biomaterial.Faculdade De Odontologia De Bauru - USP2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000200008Journal of Applied Oral Science v.16 n.2 2008reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572008000200008info:eu-repo/semantics/openAccessLeite,Fábio Renato ManzolliRamalho,Lizeti Toledo de Oliveiraeng2008-04-28T00:00:00Zoai:scielo:S1678-77572008000200008Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2008-04-28T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
title Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
spellingShingle Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
Leite,Fábio Renato Manzolli
Bone regeneration
Ricinus communis
Bone substitutes
title_short Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
title_full Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
title_fullStr Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
title_full_unstemmed Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
title_sort Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation
author Leite,Fábio Renato Manzolli
author_facet Leite,Fábio Renato Manzolli
Ramalho,Lizeti Toledo de Oliveira
author_role author
author2 Ramalho,Lizeti Toledo de Oliveira
author2_role author
dc.contributor.author.fl_str_mv Leite,Fábio Renato Manzolli
Ramalho,Lizeti Toledo de Oliveira
dc.subject.por.fl_str_mv Bone regeneration
Ricinus communis
Bone substitutes
topic Bone regeneration
Ricinus communis
Bone substitutes
description Innocuous biocompatible materials have been searched to repair or reconstruct bone defects. Their goal is to restore the function of live or dead tissues. This study compared connective tissue and bone reaction when exposed to demineralized bovine bone matrix and a polyurethane resin derived from castor bean (Ricinus communis). Forty-five rats were assigned to 3 groups of 15 animals (control, bovine bone and polyurethane). A cylindrical defect was created on mandible base and filled with bovine bone matrix and the polyurethane. Control group received no treatment. Analyses were performed after 15, 45 and 60 days (5 animals each). Histological analysis revealed connective tissue tolerance to bovine bone with local inflammatory response similar to that of the control group. After 15 days, all groups demonstrated similar outcomes, with mild inflammatory reaction, probably due to the surgical procedure rather than to the material. In the polymer group, after 60 days, scarce multinucleated cells could still be observed. In general, all groups showed good stability and osteogenic connective tissue with blood vessels into the surgical area. The results suggest biocompatibility of both materials, seen by their integration into rat mandible. Moreover, the polyurethane seems to be an alternative in bone reconstruction and it is an inexhaustible source of biomaterial.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572008000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.16 n.2 2008
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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