Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats

Detalhes bibliográficos
Autor(a) principal: Medeiros,Vanessa de Fátima Lima Paiva
Data de Publicação: 2016
Outros Autores: Azevedo,Ítalo Medeiros, Carvalho,Marília Daniela Ferreira, Egito,Eryvaldo Sócrates Tabosa, Medeiros,Aldo Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826
Resumo: ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.
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spelling Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in ratsShockHemorrhagicSepsisResuscitationSimvastatinFoods Containing CoconutRatsABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826Acta Cirúrgica Brasileira v.31 n.12 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020160120000008info:eu-repo/semantics/openAccessMedeiros,Vanessa de Fátima Lima PaivaAzevedo,Ítalo MedeirosCarvalho,Marília Daniela FerreiraEgito,Eryvaldo Sócrates TabosaMedeiros,Aldo Cunhaeng2017-01-06T00:00:00Zoai:scielo:S0102-86502016001200826Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-01-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
title Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
spellingShingle Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
Medeiros,Vanessa de Fátima Lima Paiva
Shock
Hemorrhagic
Sepsis
Resuscitation
Simvastatin
Foods Containing Coconut
Rats
title_short Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
title_full Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
title_fullStr Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
title_full_unstemmed Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
title_sort Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
author Medeiros,Vanessa de Fátima Lima Paiva
author_facet Medeiros,Vanessa de Fátima Lima Paiva
Azevedo,Ítalo Medeiros
Carvalho,Marília Daniela Ferreira
Egito,Eryvaldo Sócrates Tabosa
Medeiros,Aldo Cunha
author_role author
author2 Azevedo,Ítalo Medeiros
Carvalho,Marília Daniela Ferreira
Egito,Eryvaldo Sócrates Tabosa
Medeiros,Aldo Cunha
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Medeiros,Vanessa de Fátima Lima Paiva
Azevedo,Ítalo Medeiros
Carvalho,Marília Daniela Ferreira
Egito,Eryvaldo Sócrates Tabosa
Medeiros,Aldo Cunha
dc.subject.por.fl_str_mv Shock
Hemorrhagic
Sepsis
Resuscitation
Simvastatin
Foods Containing Coconut
Rats
topic Shock
Hemorrhagic
Sepsis
Resuscitation
Simvastatin
Foods Containing Coconut
Rats
description ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020160120000008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.12 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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