Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826 |
Resumo: | ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score. |
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Acta Cirúrgica Brasileira (Online) |
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Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in ratsShockHemorrhagicSepsisResuscitationSimvastatinFoods Containing CoconutRatsABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826Acta Cirúrgica Brasileira v.31 n.12 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020160120000008info:eu-repo/semantics/openAccessMedeiros,Vanessa de Fátima Lima PaivaAzevedo,Ítalo MedeirosCarvalho,Marília Daniela FerreiraEgito,Eryvaldo Sócrates TabosaMedeiros,Aldo Cunhaeng2017-01-06T00:00:00Zoai:scielo:S0102-86502016001200826Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-01-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
title |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
spellingShingle |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats Medeiros,Vanessa de Fátima Lima Paiva Shock Hemorrhagic Sepsis Resuscitation Simvastatin Foods Containing Coconut Rats |
title_short |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
title_full |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
title_fullStr |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
title_full_unstemmed |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
title_sort |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats |
author |
Medeiros,Vanessa de Fátima Lima Paiva |
author_facet |
Medeiros,Vanessa de Fátima Lima Paiva Azevedo,Ítalo Medeiros Carvalho,Marília Daniela Ferreira Egito,Eryvaldo Sócrates Tabosa Medeiros,Aldo Cunha |
author_role |
author |
author2 |
Azevedo,Ítalo Medeiros Carvalho,Marília Daniela Ferreira Egito,Eryvaldo Sócrates Tabosa Medeiros,Aldo Cunha |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Medeiros,Vanessa de Fátima Lima Paiva Azevedo,Ítalo Medeiros Carvalho,Marília Daniela Ferreira Egito,Eryvaldo Sócrates Tabosa Medeiros,Aldo Cunha |
dc.subject.por.fl_str_mv |
Shock Hemorrhagic Sepsis Resuscitation Simvastatin Foods Containing Coconut Rats |
topic |
Shock Hemorrhagic Sepsis Resuscitation Simvastatin Foods Containing Coconut Rats |
description |
ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001200826 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020160120000008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.31 n.12 2016 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444068143104 |