Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes

Detalhes bibliográficos
Autor(a) principal: Khadivi,Behnaz
Data de Publicação: 2017
Outros Autores: Peirouvi,Tahmineh, JavanmardI,Masumeh Zirak, Rasmi,Yousef
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000200140
Resumo: Abstract Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. Results: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Conclusion: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
id SBDPC-1_787f13bfe4469f9af78594e53b5f1f19
oai_identifier_str oai:scielo:S0102-86502017000200140
network_acronym_str SBDPC-1
network_name_str Acta Cirúrgica Brasileira (Online)
repository_id_str
spelling Short-term buserelin administration induces apoptosis and morphological changes in adult rat testesGonadotropin-Releasing HormoneTestosteroneApoptosisTestisRatsAbstract Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. Results: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Conclusion: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000200140Acta Cirúrgica Brasileira v.32 n.2 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170206info:eu-repo/semantics/openAccessKhadivi,BehnazPeirouvi,TahminehJavanmardI,Masumeh ZirakRasmi,Yousefeng2017-03-08T00:00:00Zoai:scielo:S0102-86502017000200140Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-03-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
title Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
spellingShingle Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
Khadivi,Behnaz
Gonadotropin-Releasing Hormone
Testosterone
Apoptosis
Testis
Rats
title_short Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
title_full Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
title_fullStr Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
title_full_unstemmed Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
title_sort Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
author Khadivi,Behnaz
author_facet Khadivi,Behnaz
Peirouvi,Tahmineh
JavanmardI,Masumeh Zirak
Rasmi,Yousef
author_role author
author2 Peirouvi,Tahmineh
JavanmardI,Masumeh Zirak
Rasmi,Yousef
author2_role author
author
author
dc.contributor.author.fl_str_mv Khadivi,Behnaz
Peirouvi,Tahmineh
JavanmardI,Masumeh Zirak
Rasmi,Yousef
dc.subject.por.fl_str_mv Gonadotropin-Releasing Hormone
Testosterone
Apoptosis
Testis
Rats
topic Gonadotropin-Releasing Hormone
Testosterone
Apoptosis
Testis
Rats
description Abstract Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. Results: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Conclusion: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000200140
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000200140
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020170206
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.32 n.2 2017
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
_version_ 1752126444123717632

Registros relacionados