Numeric and volumetric changes in Leydig cells during aging of rats

Detalhes bibliográficos
Autor(a) principal: Neves,Bruno Vinicius Duarte
Data de Publicação: 2017
Outros Autores: Lorenzini,Fernando, Veronez,Djanira, Miranda,Eduardo Pereira de, Neves,Gabriela Duarte, Fraga,Rogério de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000807
Resumo: Abstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 months of age. The weight and volume of the resected testicles were assessed. A stereological study of Leydig cells was conducted, which included measurements of cell number and nuclear, cytoplasmic, and total cell volumes. Results: The weight and volume of the resected testicles showed reductions with age. Only the subgroup composed of 24-month old rats showed a decrease in the nuclear volume of Leydig cells. Significant reductions in the cytoplasmic volume and total volume of Leydig cells were observed in 18- and 24-month old rats. The number of Leydig cells did not vary significantly with age. Conclusions: Aging in rats resulted in reduction of the nuclear, cytoplasmic, and total cell volumes of Leydig cells. There was no change in the total number of these cells during aging.
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spelling Numeric and volumetric changes in Leydig cells during aging of ratsAgingLeydig CellsTestisHypogonadismTestosteroneRatsAbstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 months of age. The weight and volume of the resected testicles were assessed. A stereological study of Leydig cells was conducted, which included measurements of cell number and nuclear, cytoplasmic, and total cell volumes. Results: The weight and volume of the resected testicles showed reductions with age. Only the subgroup composed of 24-month old rats showed a decrease in the nuclear volume of Leydig cells. Significant reductions in the cytoplasmic volume and total volume of Leydig cells were observed in 18- and 24-month old rats. The number of Leydig cells did not vary significantly with age. Conclusions: Aging in rats resulted in reduction of the nuclear, cytoplasmic, and total cell volumes of Leydig cells. There was no change in the total number of these cells during aging.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000807Acta Cirúrgica Brasileira v.32 n.10 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170100000002info:eu-repo/semantics/openAccessNeves,Bruno Vinicius DuarteLorenzini,FernandoVeronez,DjaniraMiranda,Eduardo Pereira deNeves,Gabriela DuarteFraga,Rogério deeng2017-11-08T00:00:00Zoai:scielo:S0102-86502017001000807Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-11-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Numeric and volumetric changes in Leydig cells during aging of rats
title Numeric and volumetric changes in Leydig cells during aging of rats
spellingShingle Numeric and volumetric changes in Leydig cells during aging of rats
Neves,Bruno Vinicius Duarte
Aging
Leydig Cells
Testis
Hypogonadism
Testosterone
Rats
title_short Numeric and volumetric changes in Leydig cells during aging of rats
title_full Numeric and volumetric changes in Leydig cells during aging of rats
title_fullStr Numeric and volumetric changes in Leydig cells during aging of rats
title_full_unstemmed Numeric and volumetric changes in Leydig cells during aging of rats
title_sort Numeric and volumetric changes in Leydig cells during aging of rats
author Neves,Bruno Vinicius Duarte
author_facet Neves,Bruno Vinicius Duarte
Lorenzini,Fernando
Veronez,Djanira
Miranda,Eduardo Pereira de
Neves,Gabriela Duarte
Fraga,Rogério de
author_role author
author2 Lorenzini,Fernando
Veronez,Djanira
Miranda,Eduardo Pereira de
Neves,Gabriela Duarte
Fraga,Rogério de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Neves,Bruno Vinicius Duarte
Lorenzini,Fernando
Veronez,Djanira
Miranda,Eduardo Pereira de
Neves,Gabriela Duarte
Fraga,Rogério de
dc.subject.por.fl_str_mv Aging
Leydig Cells
Testis
Hypogonadism
Testosterone
Rats
topic Aging
Leydig Cells
Testis
Hypogonadism
Testosterone
Rats
description Abstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 months of age. The weight and volume of the resected testicles were assessed. A stereological study of Leydig cells was conducted, which included measurements of cell number and nuclear, cytoplasmic, and total cell volumes. Results: The weight and volume of the resected testicles showed reductions with age. Only the subgroup composed of 24-month old rats showed a decrease in the nuclear volume of Leydig cells. Significant reductions in the cytoplasmic volume and total volume of Leydig cells were observed in 18- and 24-month old rats. The number of Leydig cells did not vary significantly with age. Conclusions: Aging in rats resulted in reduction of the nuclear, cytoplasmic, and total cell volumes of Leydig cells. There was no change in the total number of these cells during aging.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000807
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000807
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020170100000002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.32 n.10 2017
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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