The importance of sodium/iodide symporter (NIS) for thyroid cancer management

Detalhes bibliográficos
Autor(a) principal: Carvalho,Denise P.
Data de Publicação: 2007
Outros Autores: Ferreira,Andrea C.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500004
Resumo: The thyroid gland has the ability to uptake and concentrate iodide, which is a fundamental step in thyroid hormone biosynthesis. Radioiodine has been used as a diagnostic and therapeutic tool for several years. However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS). The studies about the regulation of NIS expression and the possibility of gene therapy with the aim of transferring NIS gene to cells that normally do not express the symporter have also become possible. In the majority of hypofunctioning thyroid nodules, both benign and malignant, NIS gene expression is maintained, but NIS protein is retained in the intracellular compartment. The expression of NIS in non-thyroid tumoral cells in vivo has been possible through the transfer of NIS gene under the control of tissue-specific promoters. Apart from its therapeutic use, NIS has also been used for the localization of metastases by scintigraphy or PET-scan with 124I. In conclusion, NIS gene cloning led to an important development in the field of thyroid pathophysiology, and has also been fundamental to extend the use of radioiodine for the management of non-thyroid tumors.
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spelling The importance of sodium/iodide symporter (NIS) for thyroid cancer managementThyroidNISCancerRadioiodineIodide uptakeGene transferThe thyroid gland has the ability to uptake and concentrate iodide, which is a fundamental step in thyroid hormone biosynthesis. Radioiodine has been used as a diagnostic and therapeutic tool for several years. However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS). The studies about the regulation of NIS expression and the possibility of gene therapy with the aim of transferring NIS gene to cells that normally do not express the symporter have also become possible. In the majority of hypofunctioning thyroid nodules, both benign and malignant, NIS gene expression is maintained, but NIS protein is retained in the intracellular compartment. The expression of NIS in non-thyroid tumoral cells in vivo has been possible through the transfer of NIS gene under the control of tissue-specific promoters. Apart from its therapeutic use, NIS has also been used for the localization of metastases by scintigraphy or PET-scan with 124I. In conclusion, NIS gene cloning led to an important development in the field of thyroid pathophysiology, and has also been fundamental to extend the use of radioiodine for the management of non-thyroid tumors.Sociedade Brasileira de Endocrinologia e Metabologia2007-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500004Arquivos Brasileiros de Endocrinologia & Metabologia v.51 n.5 2007reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302007000500004info:eu-repo/semantics/openAccessCarvalho,Denise P.Ferreira,Andrea C.F.eng2007-09-20T00:00:00Zoai:scielo:S0004-27302007000500004Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2007-09-20T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv The importance of sodium/iodide symporter (NIS) for thyroid cancer management
title The importance of sodium/iodide symporter (NIS) for thyroid cancer management
spellingShingle The importance of sodium/iodide symporter (NIS) for thyroid cancer management
Carvalho,Denise P.
Thyroid
NIS
Cancer
Radioiodine
Iodide uptake
Gene transfer
title_short The importance of sodium/iodide symporter (NIS) for thyroid cancer management
title_full The importance of sodium/iodide symporter (NIS) for thyroid cancer management
title_fullStr The importance of sodium/iodide symporter (NIS) for thyroid cancer management
title_full_unstemmed The importance of sodium/iodide symporter (NIS) for thyroid cancer management
title_sort The importance of sodium/iodide symporter (NIS) for thyroid cancer management
author Carvalho,Denise P.
author_facet Carvalho,Denise P.
Ferreira,Andrea C.F.
author_role author
author2 Ferreira,Andrea C.F.
author2_role author
dc.contributor.author.fl_str_mv Carvalho,Denise P.
Ferreira,Andrea C.F.
dc.subject.por.fl_str_mv Thyroid
NIS
Cancer
Radioiodine
Iodide uptake
Gene transfer
topic Thyroid
NIS
Cancer
Radioiodine
Iodide uptake
Gene transfer
description The thyroid gland has the ability to uptake and concentrate iodide, which is a fundamental step in thyroid hormone biosynthesis. Radioiodine has been used as a diagnostic and therapeutic tool for several years. However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS). The studies about the regulation of NIS expression and the possibility of gene therapy with the aim of transferring NIS gene to cells that normally do not express the symporter have also become possible. In the majority of hypofunctioning thyroid nodules, both benign and malignant, NIS gene expression is maintained, but NIS protein is retained in the intracellular compartment. The expression of NIS in non-thyroid tumoral cells in vivo has been possible through the transfer of NIS gene under the control of tissue-specific promoters. Apart from its therapeutic use, NIS has also been used for the localization of metastases by scintigraphy or PET-scan with 124I. In conclusion, NIS gene cloning led to an important development in the field of thyroid pathophysiology, and has also been fundamental to extend the use of radioiodine for the management of non-thyroid tumors.
publishDate 2007
dc.date.none.fl_str_mv 2007-07-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500004
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302007000500004
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.51 n.5 2007
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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