Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

Detalhes bibliográficos
Autor(a) principal: Furlanetto, Tania Weber [UNIFESP]
Data de Publicação: 2001
Outros Autores: Nunes Jr., R.b., Sopelsa, A.m.i., Maciel, Rui Monteiro de Barros [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000004jkk
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2001000200015
http://repositorio.unifesp.br/handle/11600/1100
Resumo: Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
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spelling Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cellsiodide uptakeestradiolthyroidfollicular cellsEstradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina InternaUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de EndocrinologiaUNIFESP, Depto. de Medicina Divisão de EndocrinologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina InternaUniversidade Federal de São Paulo (UNIFESP)Furlanetto, Tania Weber [UNIFESP]Nunes Jr., R.b.Sopelsa, A.m.i.Maciel, Rui Monteiro de Barros [UNIFESP]2015-06-14T13:25:10Z2015-06-14T13:25:10Z2001-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion259-263application/pdfhttp://dx.doi.org/10.1590/S0100-879X2001000200015Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.10.1590/S0100-879X2001000200015S0100-879X2001000200015.pdf0100-879XS0100-879X2001000200015http://repositorio.unifesp.br/handle/11600/1100WOS:000167337600015ark:/48912/0013000004jkkengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:39:37Zoai:repositorio.unifesp.br/:11600/1100Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:56:56.402871Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
spellingShingle Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Furlanetto, Tania Weber [UNIFESP]
iodide uptake
estradiol
thyroid
follicular cells
title_short Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_full Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_fullStr Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_full_unstemmed Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_sort Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
author Furlanetto, Tania Weber [UNIFESP]
author_facet Furlanetto, Tania Weber [UNIFESP]
Nunes Jr., R.b.
Sopelsa, A.m.i.
Maciel, Rui Monteiro de Barros [UNIFESP]
author_role author
author2 Nunes Jr., R.b.
Sopelsa, A.m.i.
Maciel, Rui Monteiro de Barros [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Furlanetto, Tania Weber [UNIFESP]
Nunes Jr., R.b.
Sopelsa, A.m.i.
Maciel, Rui Monteiro de Barros [UNIFESP]
dc.subject.por.fl_str_mv iodide uptake
estradiol
thyroid
follicular cells
topic iodide uptake
estradiol
thyroid
follicular cells
description Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
publishDate 2001
dc.date.none.fl_str_mv 2001-02-01
2015-06-14T13:25:10Z
2015-06-14T13:25:10Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2001000200015
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.
10.1590/S0100-879X2001000200015
S0100-879X2001000200015.pdf
0100-879X
S0100-879X2001000200015
http://repositorio.unifesp.br/handle/11600/1100
WOS:000167337600015
dc.identifier.dark.fl_str_mv ark:/48912/0013000004jkk
url http://dx.doi.org/10.1590/S0100-879X2001000200015
http://repositorio.unifesp.br/handle/11600/1100
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.
10.1590/S0100-879X2001000200015
S0100-879X2001000200015.pdf
0100-879X
S0100-879X2001000200015
WOS:000167337600015
ark:/48912/0013000004jkk
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 259-263
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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