Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000004jkk |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2001000200015 http://repositorio.unifesp.br/handle/11600/1100 |
Resumo: | Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis. |
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Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cellsiodide uptakeestradiolthyroidfollicular cellsEstradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina InternaUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de EndocrinologiaUNIFESP, Depto. de Medicina Divisão de EndocrinologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina InternaUniversidade Federal de São Paulo (UNIFESP)Furlanetto, Tania Weber [UNIFESP]Nunes Jr., R.b.Sopelsa, A.m.i.Maciel, Rui Monteiro de Barros [UNIFESP]2015-06-14T13:25:10Z2015-06-14T13:25:10Z2001-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion259-263application/pdfhttp://dx.doi.org/10.1590/S0100-879X2001000200015Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.10.1590/S0100-879X2001000200015S0100-879X2001000200015.pdf0100-879XS0100-879X2001000200015http://repositorio.unifesp.br/handle/11600/1100WOS:000167337600015ark:/48912/0013000004jkkengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:39:37Zoai:repositorio.unifesp.br/:11600/1100Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:56:56.402871Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
spellingShingle |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells Furlanetto, Tania Weber [UNIFESP] iodide uptake estradiol thyroid follicular cells |
title_short |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_full |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_fullStr |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_full_unstemmed |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_sort |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
author |
Furlanetto, Tania Weber [UNIFESP] |
author_facet |
Furlanetto, Tania Weber [UNIFESP] Nunes Jr., R.b. Sopelsa, A.m.i. Maciel, Rui Monteiro de Barros [UNIFESP] |
author_role |
author |
author2 |
Nunes Jr., R.b. Sopelsa, A.m.i. Maciel, Rui Monteiro de Barros [UNIFESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Furlanetto, Tania Weber [UNIFESP] Nunes Jr., R.b. Sopelsa, A.m.i. Maciel, Rui Monteiro de Barros [UNIFESP] |
dc.subject.por.fl_str_mv |
iodide uptake estradiol thyroid follicular cells |
topic |
iodide uptake estradiol thyroid follicular cells |
description |
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-02-01 2015-06-14T13:25:10Z 2015-06-14T13:25:10Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2001000200015 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001. 10.1590/S0100-879X2001000200015 S0100-879X2001000200015.pdf 0100-879X S0100-879X2001000200015 http://repositorio.unifesp.br/handle/11600/1100 WOS:000167337600015 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000004jkk |
url |
http://dx.doi.org/10.1590/S0100-879X2001000200015 http://repositorio.unifesp.br/handle/11600/1100 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001. 10.1590/S0100-879X2001000200015 S0100-879X2001000200015.pdf 0100-879X S0100-879X2001000200015 WOS:000167337600015 ark:/48912/0013000004jkk |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
259-263 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818602401677967360 |