Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release

Detalhes bibliográficos
Autor(a) principal: Shi, Jun
Data de Publicação: 2008
Outros Autores: Alves, N. M., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/14092
Resumo: Chitosan coated alginate beads containing poly(N-isopropylacrylamide) (PNIPAAM), were prepared to be used as a controlled pH/temperature sensitive drug delivery system with improved encapsulation efficiency and delayed release rate. The studied beads were characterized by differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy. Water uptake and release studies using indomethacin as a model drug were also performed. The drug loading efficiency of the beads with the polyelectrolyte complex coating is significantly higher (84%) than that of the uncoated ones (74%). The equilibrium swelling of the developed materials was found to be pH- and thermoresponsive. For all the conditions it was found that the release profile was slower for the coated beads, indicating that the polyelectrolyte complex coating could slow down the release rate effectively. These results suggest that the studied smart system has potential to be used as an effective pH/temperature sustainable delivery system for biomedical applications.
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spelling Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug releaseAlginateBiomaterialsChitosanDrug delivery systemspH/temperatureResponsivepH/temperature responsiveScience & TechnologyChitosan coated alginate beads containing poly(N-isopropylacrylamide) (PNIPAAM), were prepared to be used as a controlled pH/temperature sensitive drug delivery system with improved encapsulation efficiency and delayed release rate. The studied beads were characterized by differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy. Water uptake and release studies using indomethacin as a model drug were also performed. The drug loading efficiency of the beads with the polyelectrolyte complex coating is significantly higher (84%) than that of the uncoated ones (74%). The equilibrium swelling of the developed materials was found to be pH- and thermoresponsive. For all the conditions it was found that the release profile was slower for the coated beads, indicating that the polyelectrolyte complex coating could slow down the release rate effectively. These results suggest that the studied smart system has potential to be used as an effective pH/temperature sustainable delivery system for biomedical applications.WileyUniversidade do MinhoShi, JunAlves, N. M.Mano, J. F.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/14092engShi, J., Alves, N. M., & Mano, J. F. (2008). Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release. Journal of Biomedical Materials Research Part B: Applied Biomaterials. Wiley. http://doi.org/10.1002/jbm.b.309071552-49731552-498110.1002/jbm.b.3090717618514https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.30907info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:20Zoai:repositorium.sdum.uminho.pt:1822/14092Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:50.718062Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
title Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
spellingShingle Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
Shi, Jun
Alginate
Biomaterials
Chitosan
Drug delivery systems
pH/temperature
Responsive
pH/temperature responsive
Science & Technology
title_short Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
title_full Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
title_fullStr Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
title_full_unstemmed Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
title_sort Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release
author Shi, Jun
author_facet Shi, Jun
Alves, N. M.
Mano, J. F.
author_role author
author2 Alves, N. M.
Mano, J. F.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Shi, Jun
Alves, N. M.
Mano, J. F.
dc.subject.por.fl_str_mv Alginate
Biomaterials
Chitosan
Drug delivery systems
pH/temperature
Responsive
pH/temperature responsive
Science & Technology
topic Alginate
Biomaterials
Chitosan
Drug delivery systems
pH/temperature
Responsive
pH/temperature responsive
Science & Technology
description Chitosan coated alginate beads containing poly(N-isopropylacrylamide) (PNIPAAM), were prepared to be used as a controlled pH/temperature sensitive drug delivery system with improved encapsulation efficiency and delayed release rate. The studied beads were characterized by differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy. Water uptake and release studies using indomethacin as a model drug were also performed. The drug loading efficiency of the beads with the polyelectrolyte complex coating is significantly higher (84%) than that of the uncoated ones (74%). The equilibrium swelling of the developed materials was found to be pH- and thermoresponsive. For all the conditions it was found that the release profile was slower for the coated beads, indicating that the polyelectrolyte complex coating could slow down the release rate effectively. These results suggest that the studied smart system has potential to be used as an effective pH/temperature sustainable delivery system for biomedical applications.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/14092
url https://hdl.handle.net/1822/14092
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Shi, J., Alves, N. M., & Mano, J. F. (2008). Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuli-responsive drug release. Journal of Biomedical Materials Research Part B: Applied Biomaterials. Wiley. http://doi.org/10.1002/jbm.b.30907
1552-4973
1552-4981
10.1002/jbm.b.30907
17618514
https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.30907
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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