Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Garrido,Valéria
Data de Publicação: 2011
Outros Autores: Teixeira,Gerlinde A. P. B., Teixeira,Valéria L., Ocampo,Patrícia, Ferreira,Wilton J., Cavalcanti,Diana N., Campos,Sylvia M. N., Pedruzzi,Monique de M. B., Olaya,Patricia, Santos,Claudio C. C.dos, Giongo,Viveca, Paixão,Izabel C. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000200003
Resumo: Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.
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spelling Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c miceDictyota pfaffiidolabelladienotriolacute toxicityBALB/c micediterpeneantiviralDolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.Sociedade Brasileira de Farmacognosia2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000200003Revista Brasileira de Farmacognosia v.21 n.2 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000053info:eu-repo/semantics/openAccessGarrido,ValériaTeixeira,Gerlinde A. P. B.Teixeira,Valéria L.Ocampo,PatríciaFerreira,Wilton J.Cavalcanti,Diana N.Campos,Sylvia M. N.Pedruzzi,Monique de M. B.Olaya,PatriciaSantos,Claudio C. C.dosGiongo,VivecaPaixão,Izabel C. P.eng2011-06-03T00:00:00Zoai:scielo:S0102-695X2011000200003Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-06-03T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
title Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
spellingShingle Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
Garrido,Valéria
Dictyota pfaffii
dolabelladienotriol
acute toxicity
BALB/c mice
diterpene
antiviral
title_short Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
title_full Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
title_fullStr Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
title_full_unstemmed Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
title_sort Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
author Garrido,Valéria
author_facet Garrido,Valéria
Teixeira,Gerlinde A. P. B.
Teixeira,Valéria L.
Ocampo,Patrícia
Ferreira,Wilton J.
Cavalcanti,Diana N.
Campos,Sylvia M. N.
Pedruzzi,Monique de M. B.
Olaya,Patricia
Santos,Claudio C. C.dos
Giongo,Viveca
Paixão,Izabel C. P.
author_role author
author2 Teixeira,Gerlinde A. P. B.
Teixeira,Valéria L.
Ocampo,Patrícia
Ferreira,Wilton J.
Cavalcanti,Diana N.
Campos,Sylvia M. N.
Pedruzzi,Monique de M. B.
Olaya,Patricia
Santos,Claudio C. C.dos
Giongo,Viveca
Paixão,Izabel C. P.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Garrido,Valéria
Teixeira,Gerlinde A. P. B.
Teixeira,Valéria L.
Ocampo,Patrícia
Ferreira,Wilton J.
Cavalcanti,Diana N.
Campos,Sylvia M. N.
Pedruzzi,Monique de M. B.
Olaya,Patricia
Santos,Claudio C. C.dos
Giongo,Viveca
Paixão,Izabel C. P.
dc.subject.por.fl_str_mv Dictyota pfaffii
dolabelladienotriol
acute toxicity
BALB/c mice
diterpene
antiviral
topic Dictyota pfaffii
dolabelladienotriol
acute toxicity
BALB/c mice
diterpene
antiviral
description Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.2 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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