Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran

Detalhes bibliográficos
Autor(a) principal: Khodaie,Laleh
Data de Publicação: 2012
Outros Autores: Delazar,Abbas, Lotfipour,Farzane, Nazemiyeh,Hossein, Asnaashari,Solmaz, Moghadam,Sedighe B., Nahar,Lutfun, Sarker,Satyajit D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600009
Resumo: The methanol extract of the aerial parts of the medicinal plant Pedicularis sibthorpii Boiss., Scrophulariaceae, growing in the Azerbaijan province of Iran, was found to be active in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and the antibacterial agar well diffusion assays, but no general toxicity was observed in the brine shrimp lethality assay. A combination of solid-phase extraction (SPE) and preparative reversed-phase high-performance liquid chromatography (prep-RP-HPLC) analyses of the methanolic extract afforded three phenylethanoids (verbascoside, martynoside and isomartynoside), an iridoid (aucubin), a flavonoid (luteolin 7-O-β-D-glucopyranoside) and mannitol, and the structures of these compounds were elucidated unambiguously by spectroscopic means. The distribution of the isolated compounds within the genus Pedicularis has also been discussed.
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spelling Phytochemistry and bioactivity of Pedicularis sibthorpii growing in IranPedicularis sibthorpiifree-radical-scavengerantimicrobialbrine shrimp lethalityiridoidphenylpropanoidflavonoidThe methanol extract of the aerial parts of the medicinal plant Pedicularis sibthorpii Boiss., Scrophulariaceae, growing in the Azerbaijan province of Iran, was found to be active in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and the antibacterial agar well diffusion assays, but no general toxicity was observed in the brine shrimp lethality assay. A combination of solid-phase extraction (SPE) and preparative reversed-phase high-performance liquid chromatography (prep-RP-HPLC) analyses of the methanolic extract afforded three phenylethanoids (verbascoside, martynoside and isomartynoside), an iridoid (aucubin), a flavonoid (luteolin 7-O-β-D-glucopyranoside) and mannitol, and the structures of these compounds were elucidated unambiguously by spectroscopic means. The distribution of the isolated compounds within the genus Pedicularis has also been discussed.Sociedade Brasileira de Farmacognosia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600009Revista Brasileira de Farmacognosia v.22 n.6 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000107info:eu-repo/semantics/openAccessKhodaie,LalehDelazar,AbbasLotfipour,FarzaneNazemiyeh,HosseinAsnaashari,SolmazMoghadam,Sedighe B.Nahar,LutfunSarker,Satyajit D.eng2012-12-06T00:00:00Zoai:scielo:S0102-695X2012000600009Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
title Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
spellingShingle Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
Khodaie,Laleh
Pedicularis sibthorpii
free-radical-scavenger
antimicrobial
brine shrimp lethality
iridoid
phenylpropanoid
flavonoid
title_short Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
title_full Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
title_fullStr Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
title_full_unstemmed Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
title_sort Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran
author Khodaie,Laleh
author_facet Khodaie,Laleh
Delazar,Abbas
Lotfipour,Farzane
Nazemiyeh,Hossein
Asnaashari,Solmaz
Moghadam,Sedighe B.
Nahar,Lutfun
Sarker,Satyajit D.
author_role author
author2 Delazar,Abbas
Lotfipour,Farzane
Nazemiyeh,Hossein
Asnaashari,Solmaz
Moghadam,Sedighe B.
Nahar,Lutfun
Sarker,Satyajit D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Khodaie,Laleh
Delazar,Abbas
Lotfipour,Farzane
Nazemiyeh,Hossein
Asnaashari,Solmaz
Moghadam,Sedighe B.
Nahar,Lutfun
Sarker,Satyajit D.
dc.subject.por.fl_str_mv Pedicularis sibthorpii
free-radical-scavenger
antimicrobial
brine shrimp lethality
iridoid
phenylpropanoid
flavonoid
topic Pedicularis sibthorpii
free-radical-scavenger
antimicrobial
brine shrimp lethality
iridoid
phenylpropanoid
flavonoid
description The methanol extract of the aerial parts of the medicinal plant Pedicularis sibthorpii Boiss., Scrophulariaceae, growing in the Azerbaijan province of Iran, was found to be active in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and the antibacterial agar well diffusion assays, but no general toxicity was observed in the brine shrimp lethality assay. A combination of solid-phase extraction (SPE) and preparative reversed-phase high-performance liquid chromatography (prep-RP-HPLC) analyses of the methanolic extract afforded three phenylethanoids (verbascoside, martynoside and isomartynoside), an iridoid (aucubin), a flavonoid (luteolin 7-O-β-D-glucopyranoside) and mannitol, and the structures of these compounds were elucidated unambiguously by spectroscopic means. The distribution of the isolated compounds within the genus Pedicularis has also been discussed.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000107
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.6 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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