Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

Detalhes bibliográficos
Autor(a) principal: Mahesh,Ayyavu
Data de Publicação: 2012
Outros Autores: Jeyachandran,Robert, Rao,Dowlathabad Muralidhara, Thangadurai,Devarajan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500021
Resumo: In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed significant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.
id SBFGNOSIA-1_390ebb4ce3fe3d05c4d09f621528ca64
oai_identifier_str oai:scielo:S0102-695X2012000500021
network_acronym_str SBFGNOSIA-1
network_name_str Revista Brasileira de Farmacognosia (Online)
repository_id_str
spelling Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse modelsDesmodium gangeticumgastric ulcergastroprotective activityFabaceaeOmeprazoleIn the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed significant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.Sociedade Brasileira de Farmacognosia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500021Revista Brasileira de Farmacognosia v.22 n.5 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000081info:eu-repo/semantics/openAccessMahesh,AyyavuJeyachandran,RobertRao,Dowlathabad MuralidharaThangadurai,Devarajaneng2012-09-18T00:00:00Zoai:scielo:S0102-695X2012000500021Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-09-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
title Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
spellingShingle Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
Mahesh,Ayyavu
Desmodium gangeticum
gastric ulcer
gastroprotective activity
Fabaceae
Omeprazole
title_short Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
title_full Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
title_fullStr Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
title_full_unstemmed Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
title_sort Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
author Mahesh,Ayyavu
author_facet Mahesh,Ayyavu
Jeyachandran,Robert
Rao,Dowlathabad Muralidhara
Thangadurai,Devarajan
author_role author
author2 Jeyachandran,Robert
Rao,Dowlathabad Muralidhara
Thangadurai,Devarajan
author2_role author
author
author
dc.contributor.author.fl_str_mv Mahesh,Ayyavu
Jeyachandran,Robert
Rao,Dowlathabad Muralidhara
Thangadurai,Devarajan
dc.subject.por.fl_str_mv Desmodium gangeticum
gastric ulcer
gastroprotective activity
Fabaceae
Omeprazole
topic Desmodium gangeticum
gastric ulcer
gastroprotective activity
Fabaceae
Omeprazole
description In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed significant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000081
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.5 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
_version_ 1752122467819716608

Registros relacionados