The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300013 |
Resumo: | The anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The anti-inflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. bovis was detected in vitro by an interferometric method in liquid culture medium. The chemical constituents of the essential oil were determined by GC/MS. Higher yields of the essential oil of S. cumini leaves were obtained by extraction in a Clevenger apparatus when the fresh leaves were previously frozen as a pre-processing step. The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system. |
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The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in miceanti-inflammatorygranulomainterferometrycaryophylleneMycobacterium bovisSyzygium cuminiThe anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The anti-inflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. bovis was detected in vitro by an interferometric method in liquid culture medium. The chemical constituents of the essential oil were determined by GC/MS. Higher yields of the essential oil of S. cumini leaves were obtained by extraction in a Clevenger apparatus when the fresh leaves were previously frozen as a pre-processing step. The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system.Sociedade Brasileira de Farmacognosia2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300013Revista Brasileira de Farmacognosia v.23 n.3 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000030info:eu-repo/semantics/openAccessMachado,Rachel R. P.Jardim,Deborah F.Souza,Andrezza R.Scio,ElitaFabri,Rodrigo L.Carpanez,Arthur G.Grazul,Richard M.Mendonça,José Paulo R. F. deLesche,BernhardAarestrup,Fernando M.eng2013-06-11T00:00:00Zoai:scielo:S0102-695X2013000300013Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-06-11T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
title |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
spellingShingle |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice Machado,Rachel R. P. anti-inflammatory granuloma interferometry caryophyllene Mycobacterium bovis Syzygium cumini |
title_short |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
title_full |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
title_fullStr |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
title_full_unstemmed |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
title_sort |
The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice |
author |
Machado,Rachel R. P. |
author_facet |
Machado,Rachel R. P. Jardim,Deborah F. Souza,Andrezza R. Scio,Elita Fabri,Rodrigo L. Carpanez,Arthur G. Grazul,Richard M. Mendonça,José Paulo R. F. de Lesche,Bernhard Aarestrup,Fernando M. |
author_role |
author |
author2 |
Jardim,Deborah F. Souza,Andrezza R. Scio,Elita Fabri,Rodrigo L. Carpanez,Arthur G. Grazul,Richard M. Mendonça,José Paulo R. F. de Lesche,Bernhard Aarestrup,Fernando M. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Machado,Rachel R. P. Jardim,Deborah F. Souza,Andrezza R. Scio,Elita Fabri,Rodrigo L. Carpanez,Arthur G. Grazul,Richard M. Mendonça,José Paulo R. F. de Lesche,Bernhard Aarestrup,Fernando M. |
dc.subject.por.fl_str_mv |
anti-inflammatory granuloma interferometry caryophyllene Mycobacterium bovis Syzygium cumini |
topic |
anti-inflammatory granuloma interferometry caryophyllene Mycobacterium bovis Syzygium cumini |
description |
The anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The anti-inflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. bovis was detected in vitro by an interferometric method in liquid culture medium. The chemical constituents of the essential oil were determined by GC/MS. Higher yields of the essential oil of S. cumini leaves were obtained by extraction in a Clevenger apparatus when the fresh leaves were previously frozen as a pre-processing step. The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2013005000030 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.23 n.3 2013 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122468748754944 |