Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens

Detalhes bibliográficos
Autor(a) principal: Liu,Yang
Data de Publicação: 2017
Outros Autores: Liu,Xiao-Hong, Zhou,San, Gao,Hua, Li,Guo-Liang, Guo,Wei-Jie, Fang,Xin-Yu, Wang,Wei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564
Resumo: Abstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities.
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spelling Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescensMonoterpene glycosidePerillanolide APerillanolide BXanthine oxidaseAbstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities.Sociedade Brasileira de Farmacognosia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564Revista Brasileira de Farmacognosia v.27 n.5 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2017.06.003info:eu-repo/semantics/openAccessLiu,YangLiu,Xiao-HongZhou,SanGao,HuaLi,Guo-LiangGuo,Wei-JieFang,Xin-YuWang,Weieng2017-11-14T00:00:00Zoai:scielo:S0102-695X2017000500564Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2017-11-14T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
title Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
spellingShingle Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
Liu,Yang
Monoterpene glycoside
Perillanolide A
Perillanolide B
Xanthine oxidase
title_short Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
title_full Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
title_fullStr Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
title_full_unstemmed Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
title_sort Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
author Liu,Yang
author_facet Liu,Yang
Liu,Xiao-Hong
Zhou,San
Gao,Hua
Li,Guo-Liang
Guo,Wei-Jie
Fang,Xin-Yu
Wang,Wei
author_role author
author2 Liu,Xiao-Hong
Zhou,San
Gao,Hua
Li,Guo-Liang
Guo,Wei-Jie
Fang,Xin-Yu
Wang,Wei
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Liu,Yang
Liu,Xiao-Hong
Zhou,San
Gao,Hua
Li,Guo-Liang
Guo,Wei-Jie
Fang,Xin-Yu
Wang,Wei
dc.subject.por.fl_str_mv Monoterpene glycoside
Perillanolide A
Perillanolide B
Xanthine oxidase
topic Monoterpene glycoside
Perillanolide A
Perillanolide B
Xanthine oxidase
description Abstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2017.06.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.27 n.5 2017
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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