Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564 |
Resumo: | Abstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities. |
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Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescensMonoterpene glycosidePerillanolide APerillanolide BXanthine oxidaseAbstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities.Sociedade Brasileira de Farmacognosia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564Revista Brasileira de Farmacognosia v.27 n.5 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2017.06.003info:eu-repo/semantics/openAccessLiu,YangLiu,Xiao-HongZhou,SanGao,HuaLi,Guo-LiangGuo,Wei-JieFang,Xin-YuWang,Weieng2017-11-14T00:00:00Zoai:scielo:S0102-695X2017000500564Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2017-11-14T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
title |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
spellingShingle |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens Liu,Yang Monoterpene glycoside Perillanolide A Perillanolide B Xanthine oxidase |
title_short |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
title_full |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
title_fullStr |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
title_full_unstemmed |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
title_sort |
Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens |
author |
Liu,Yang |
author_facet |
Liu,Yang Liu,Xiao-Hong Zhou,San Gao,Hua Li,Guo-Liang Guo,Wei-Jie Fang,Xin-Yu Wang,Wei |
author_role |
author |
author2 |
Liu,Xiao-Hong Zhou,San Gao,Hua Li,Guo-Liang Guo,Wei-Jie Fang,Xin-Yu Wang,Wei |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Liu,Yang Liu,Xiao-Hong Zhou,San Gao,Hua Li,Guo-Liang Guo,Wei-Jie Fang,Xin-Yu Wang,Wei |
dc.subject.por.fl_str_mv |
Monoterpene glycoside Perillanolide A Perillanolide B Xanthine oxidase |
topic |
Monoterpene glycoside Perillanolide A Perillanolide B Xanthine oxidase |
description |
Abstract Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500564 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2017.06.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.27 n.5 2017 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122470548111360 |