Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006 |
Resumo: | Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. |
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Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrysalkaloidsantiproliferative activityditerpenesmedicinal plantsCroton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.Sociedade Brasileira de Farmacognosia2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006Revista Brasileira de Farmacognosia v.21 n.6 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000174info:eu-repo/semantics/openAccessMotta,Lucimar B.Furlan,Cláudia M.Santos,Deborah Y. A. C.Salatino,Maria L. F.Duarte-Almeida,Joaquim M.Negri,GiuseppinaCarvalho,João E. deRuiz,Ana Lúcia T. G.Cordeiro,InêsSalatino,Antonioeng2011-10-18T00:00:00Zoai:scielo:S0102-695X2011000600006Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-10-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
title |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
spellingShingle |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys Motta,Lucimar B. alkaloids antiproliferative activity diterpenes medicinal plants |
title_short |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
title_full |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
title_fullStr |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
title_full_unstemmed |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
title_sort |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
author |
Motta,Lucimar B. |
author_facet |
Motta,Lucimar B. Furlan,Cláudia M. Santos,Deborah Y. A. C. Salatino,Maria L. F. Duarte-Almeida,Joaquim M. Negri,Giuseppina Carvalho,João E. de Ruiz,Ana Lúcia T. G. Cordeiro,Inês Salatino,Antonio |
author_role |
author |
author2 |
Furlan,Cláudia M. Santos,Deborah Y. A. C. Salatino,Maria L. F. Duarte-Almeida,Joaquim M. Negri,Giuseppina Carvalho,João E. de Ruiz,Ana Lúcia T. G. Cordeiro,Inês Salatino,Antonio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Motta,Lucimar B. Furlan,Cláudia M. Santos,Deborah Y. A. C. Salatino,Maria L. F. Duarte-Almeida,Joaquim M. Negri,Giuseppina Carvalho,João E. de Ruiz,Ana Lúcia T. G. Cordeiro,Inês Salatino,Antonio |
dc.subject.por.fl_str_mv |
alkaloids antiproliferative activity diterpenes medicinal plants |
topic |
alkaloids antiproliferative activity diterpenes medicinal plants |
description |
Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2011005000174 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.21 n.6 2011 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122466457616384 |