Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

Detalhes bibliográficos
Autor(a) principal: Motta,Lucimar B.
Data de Publicação: 2011
Outros Autores: Furlan,Cláudia M., Santos,Deborah Y. A. C., Salatino,Maria L. F., Duarte-Almeida,Joaquim M., Negri,Giuseppina, Carvalho,João E. de, Ruiz,Ana Lúcia T. G., Cordeiro,Inês, Salatino,Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006
Resumo: Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.
id SBFGNOSIA-1_81dad253bf3e961c8861043c4357e4ab
oai_identifier_str oai:scielo:S0102-695X2011000600006
network_acronym_str SBFGNOSIA-1
network_name_str Revista Brasileira de Farmacognosia (Online)
repository_id_str
spelling Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrysalkaloidsantiproliferative activityditerpenesmedicinal plantsCroton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.Sociedade Brasileira de Farmacognosia2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006Revista Brasileira de Farmacognosia v.21 n.6 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000174info:eu-repo/semantics/openAccessMotta,Lucimar B.Furlan,Cláudia M.Santos,Deborah Y. A. C.Salatino,Maria L. F.Duarte-Almeida,Joaquim M.Negri,GiuseppinaCarvalho,João E. deRuiz,Ana Lúcia T. G.Cordeiro,InêsSalatino,Antonioeng2011-10-18T00:00:00Zoai:scielo:S0102-695X2011000600006Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-10-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
title Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
spellingShingle Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
Motta,Lucimar B.
alkaloids
antiproliferative activity
diterpenes
medicinal plants
title_short Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
title_full Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
title_fullStr Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
title_full_unstemmed Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
title_sort Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
author Motta,Lucimar B.
author_facet Motta,Lucimar B.
Furlan,Cláudia M.
Santos,Deborah Y. A. C.
Salatino,Maria L. F.
Duarte-Almeida,Joaquim M.
Negri,Giuseppina
Carvalho,João E. de
Ruiz,Ana Lúcia T. G.
Cordeiro,Inês
Salatino,Antonio
author_role author
author2 Furlan,Cláudia M.
Santos,Deborah Y. A. C.
Salatino,Maria L. F.
Duarte-Almeida,Joaquim M.
Negri,Giuseppina
Carvalho,João E. de
Ruiz,Ana Lúcia T. G.
Cordeiro,Inês
Salatino,Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Motta,Lucimar B.
Furlan,Cláudia M.
Santos,Deborah Y. A. C.
Salatino,Maria L. F.
Duarte-Almeida,Joaquim M.
Negri,Giuseppina
Carvalho,João E. de
Ruiz,Ana Lúcia T. G.
Cordeiro,Inês
Salatino,Antonio
dc.subject.por.fl_str_mv alkaloids
antiproliferative activity
diterpenes
medicinal plants
topic alkaloids
antiproliferative activity
diterpenes
medicinal plants
description Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000174
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.6 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
_version_ 1752122466457616384

Registros relacionados