Antiproliferative potential of solidagenone isolated of Solidago chilensis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703 |
Resumo: | ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis. |
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Antiproliferative potential of solidagenone isolated of Solidago chilensisMedicinal plantsAntiproliferativePhytochemicalDiterpeneMCF-7 cell lineRule of fiveABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.Sociedade Brasileira de Farmacognosia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703Revista Brasileira de Farmacognosia v.28 n.6 2018reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.09.001info:eu-repo/semantics/openAccessGomes,Denise B.Zanchet,BarbaraLocateli,GelvaniBenvenutti,Régis C.Vechia,Cristian A. DallaSchönell,Amanda P.Diel,Kriptsan A.P.Zilli,Gabriela A.L.Miorando,DanielaErnetti,JackelineOliveira,BiancaZanotelli,PatríciaSantos,Maria F.C.Barisson,AnderssonBanzato,Thais P.Ruiz,Ana L.T.G.Carvalho,João E.Cechinel Filho,ValdirGarcía,Pablo A.G.Feliciano,Arturo SanRoman Junior,Walter A.eng2018-11-13T00:00:00Zoai:scielo:S0102-695X2018000600703Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-11-13T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
title |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
spellingShingle |
Antiproliferative potential of solidagenone isolated of Solidago chilensis Gomes,Denise B. Medicinal plants Antiproliferative Phytochemical Diterpene MCF-7 cell line Rule of five |
title_short |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
title_full |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
title_fullStr |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
title_full_unstemmed |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
title_sort |
Antiproliferative potential of solidagenone isolated of Solidago chilensis |
author |
Gomes,Denise B. |
author_facet |
Gomes,Denise B. Zanchet,Barbara Locateli,Gelvani Benvenutti,Régis C. Vechia,Cristian A. Dalla Schönell,Amanda P. Diel,Kriptsan A.P. Zilli,Gabriela A.L. Miorando,Daniela Ernetti,Jackeline Oliveira,Bianca Zanotelli,Patrícia Santos,Maria F.C. Barisson,Andersson Banzato,Thais P. Ruiz,Ana L.T.G. Carvalho,João E. Cechinel Filho,Valdir García,Pablo A.G. Feliciano,Arturo San Roman Junior,Walter A. |
author_role |
author |
author2 |
Zanchet,Barbara Locateli,Gelvani Benvenutti,Régis C. Vechia,Cristian A. Dalla Schönell,Amanda P. Diel,Kriptsan A.P. Zilli,Gabriela A.L. Miorando,Daniela Ernetti,Jackeline Oliveira,Bianca Zanotelli,Patrícia Santos,Maria F.C. Barisson,Andersson Banzato,Thais P. Ruiz,Ana L.T.G. Carvalho,João E. Cechinel Filho,Valdir García,Pablo A.G. Feliciano,Arturo San Roman Junior,Walter A. |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes,Denise B. Zanchet,Barbara Locateli,Gelvani Benvenutti,Régis C. Vechia,Cristian A. Dalla Schönell,Amanda P. Diel,Kriptsan A.P. Zilli,Gabriela A.L. Miorando,Daniela Ernetti,Jackeline Oliveira,Bianca Zanotelli,Patrícia Santos,Maria F.C. Barisson,Andersson Banzato,Thais P. Ruiz,Ana L.T.G. Carvalho,João E. Cechinel Filho,Valdir García,Pablo A.G. Feliciano,Arturo San Roman Junior,Walter A. |
dc.subject.por.fl_str_mv |
Medicinal plants Antiproliferative Phytochemical Diterpene MCF-7 cell line Rule of five |
topic |
Medicinal plants Antiproliferative Phytochemical Diterpene MCF-7 cell line Rule of five |
description |
ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2018.09.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.28 n.6 2018 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122471059816448 |