Antiproliferative potential of solidagenone isolated of Solidago chilensis

Detalhes bibliográficos
Autor(a) principal: Gomes,Denise B.
Data de Publicação: 2018
Outros Autores: Zanchet,Barbara, Locateli,Gelvani, Benvenutti,Régis C., Vechia,Cristian A. Dalla, Schönell,Amanda P., Diel,Kriptsan A.P., Zilli,Gabriela A.L., Miorando,Daniela, Ernetti,Jackeline, Oliveira,Bianca, Zanotelli,Patrícia, Santos,Maria F.C., Barisson,Andersson, Banzato,Thais P., Ruiz,Ana L.T.G., Carvalho,João E., Cechinel Filho,Valdir, García,Pablo A.G., Feliciano,Arturo San, Roman Junior,Walter A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703
Resumo: ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.
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spelling Antiproliferative potential of solidagenone isolated of Solidago chilensisMedicinal plantsAntiproliferativePhytochemicalDiterpeneMCF-7 cell lineRule of fiveABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.Sociedade Brasileira de Farmacognosia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703Revista Brasileira de Farmacognosia v.28 n.6 2018reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.09.001info:eu-repo/semantics/openAccessGomes,Denise B.Zanchet,BarbaraLocateli,GelvaniBenvenutti,Régis C.Vechia,Cristian A. DallaSchönell,Amanda P.Diel,Kriptsan A.P.Zilli,Gabriela A.L.Miorando,DanielaErnetti,JackelineOliveira,BiancaZanotelli,PatríciaSantos,Maria F.C.Barisson,AnderssonBanzato,Thais P.Ruiz,Ana L.T.G.Carvalho,João E.Cechinel Filho,ValdirGarcía,Pablo A.G.Feliciano,Arturo SanRoman Junior,Walter A.eng2018-11-13T00:00:00Zoai:scielo:S0102-695X2018000600703Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-11-13T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antiproliferative potential of solidagenone isolated of Solidago chilensis
title Antiproliferative potential of solidagenone isolated of Solidago chilensis
spellingShingle Antiproliferative potential of solidagenone isolated of Solidago chilensis
Gomes,Denise B.
Medicinal plants
Antiproliferative
Phytochemical
Diterpene
MCF-7 cell line
Rule of five
title_short Antiproliferative potential of solidagenone isolated of Solidago chilensis
title_full Antiproliferative potential of solidagenone isolated of Solidago chilensis
title_fullStr Antiproliferative potential of solidagenone isolated of Solidago chilensis
title_full_unstemmed Antiproliferative potential of solidagenone isolated of Solidago chilensis
title_sort Antiproliferative potential of solidagenone isolated of Solidago chilensis
author Gomes,Denise B.
author_facet Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Benvenutti,Régis C.
Vechia,Cristian A. Dalla
Schönell,Amanda P.
Diel,Kriptsan A.P.
Zilli,Gabriela A.L.
Miorando,Daniela
Ernetti,Jackeline
Oliveira,Bianca
Zanotelli,Patrícia
Santos,Maria F.C.
Barisson,Andersson
Banzato,Thais P.
Ruiz,Ana L.T.G.
Carvalho,João E.
Cechinel Filho,Valdir
García,Pablo A.G.
Feliciano,Arturo San
Roman Junior,Walter A.
author_role author
author2 Zanchet,Barbara
Locateli,Gelvani
Benvenutti,Régis C.
Vechia,Cristian A. Dalla
Schönell,Amanda P.
Diel,Kriptsan A.P.
Zilli,Gabriela A.L.
Miorando,Daniela
Ernetti,Jackeline
Oliveira,Bianca
Zanotelli,Patrícia
Santos,Maria F.C.
Barisson,Andersson
Banzato,Thais P.
Ruiz,Ana L.T.G.
Carvalho,João E.
Cechinel Filho,Valdir
García,Pablo A.G.
Feliciano,Arturo San
Roman Junior,Walter A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Benvenutti,Régis C.
Vechia,Cristian A. Dalla
Schönell,Amanda P.
Diel,Kriptsan A.P.
Zilli,Gabriela A.L.
Miorando,Daniela
Ernetti,Jackeline
Oliveira,Bianca
Zanotelli,Patrícia
Santos,Maria F.C.
Barisson,Andersson
Banzato,Thais P.
Ruiz,Ana L.T.G.
Carvalho,João E.
Cechinel Filho,Valdir
García,Pablo A.G.
Feliciano,Arturo San
Roman Junior,Walter A.
dc.subject.por.fl_str_mv Medicinal plants
Antiproliferative
Phytochemical
Diterpene
MCF-7 cell line
Rule of five
topic Medicinal plants
Antiproliferative
Phytochemical
Diterpene
MCF-7 cell line
Rule of five
description ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600703
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2018.09.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.28 n.6 2018
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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