Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Detalhes bibliográficos
Autor(a) principal: Favacho,Hugo A. S.
Data de Publicação: 2011
Outros Autores: Oliveira,Bianca R., Santos,Kelem C., Medeiros,Benedito J. L., Sousa,Pergentino J. C., Perazzo,Fabio F., Carvalho,José Carlos T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000100018
Resumo: The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
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spelling Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oilEuterpe oleracea Mart.oilaçaí berryinflammatorynociceptiveArecaceaeThe oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.Sociedade Brasileira de Farmacognosia2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000100018Revista Brasileira de Farmacognosia v.21 n.1 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000007info:eu-repo/semantics/openAccessFavacho,Hugo A. S.Oliveira,Bianca R.Santos,Kelem C.Medeiros,Benedito J. L.Sousa,Pergentino J. C.Perazzo,Fabio F.Carvalho,José Carlos T.eng2011-03-28T00:00:00Zoai:scielo:S0102-695X2011000100018Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-03-28T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
spellingShingle Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
Favacho,Hugo A. S.
Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
title_short Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_fullStr Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full_unstemmed Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_sort Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
author Favacho,Hugo A. S.
author_facet Favacho,Hugo A. S.
Oliveira,Bianca R.
Santos,Kelem C.
Medeiros,Benedito J. L.
Sousa,Pergentino J. C.
Perazzo,Fabio F.
Carvalho,José Carlos T.
author_role author
author2 Oliveira,Bianca R.
Santos,Kelem C.
Medeiros,Benedito J. L.
Sousa,Pergentino J. C.
Perazzo,Fabio F.
Carvalho,José Carlos T.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Favacho,Hugo A. S.
Oliveira,Bianca R.
Santos,Kelem C.
Medeiros,Benedito J. L.
Sousa,Pergentino J. C.
Perazzo,Fabio F.
Carvalho,José Carlos T.
dc.subject.por.fl_str_mv Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
topic Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
description The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000100018
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.1 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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