Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Detalhes bibliográficos
Autor(a) principal: Favacho, Hugo Alexandre Silva
Data de Publicação: 2011
Outros Autores: Oliveira, Bianca R., Santos, Kelem Costa dos, Medeiros, Benedito Junior Lima de, Sousa, Pergentino Jose da Cunha, Perazzo, Fábio Ferreira [UNIFESP], Carvalho, José Carlos Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-695X2011005000007
http://repositorio.unifesp.br/handle/11600/6279
Resumo: The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
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spelling Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oilEuterpe oleracea Mart.oilaçaí berryinflammatorynociceptiveArecaceaeThe oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.Universidade Federal do Amapá Laboratório de Pesquisa em FármacosUniversidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências FarmacêuticasUniversidade Federal do Pará Faculdade de Farmácia Laboratório de FarmacodinâmicaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraUNIFESP, Depto. de Ciências Exatas e da TerraSciELOSociedade Brasileira de FarmacognosiaUniversidade Federal do Amapá Laboratório de Pesquisa em FármacosUniversidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências FarmacêuticasUniversidade Federal do Pará Faculdade de Farmácia Laboratório de FarmacodinâmicaUniversidade Federal de São Paulo (UNIFESP)Favacho, Hugo Alexandre SilvaOliveira, Bianca R.Santos, Kelem Costa dosMedeiros, Benedito Junior Lima deSousa, Pergentino Jose da CunhaPerazzo, Fábio Ferreira [UNIFESP]Carvalho, José Carlos Tavares2015-06-14T13:42:54Z2015-06-14T13:42:54Z2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion105-114application/pdfhttp://dx.doi.org/10.1590/S0102-695X2011005000007Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011.10.1590/S0102-695X2011005000007S0102-695X2011000100018.pdf0102-695XS0102-695X2011000100018http://repositorio.unifesp.br/handle/11600/6279WOS:000289152900018engRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T19:35:34Zoai:repositorio.unifesp.br/:11600/6279Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T19:35:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
spellingShingle Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
Favacho, Hugo Alexandre Silva
Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
title_short Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_fullStr Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_full_unstemmed Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
title_sort Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
author Favacho, Hugo Alexandre Silva
author_facet Favacho, Hugo Alexandre Silva
Oliveira, Bianca R.
Santos, Kelem Costa dos
Medeiros, Benedito Junior Lima de
Sousa, Pergentino Jose da Cunha
Perazzo, Fábio Ferreira [UNIFESP]
Carvalho, José Carlos Tavares
author_role author
author2 Oliveira, Bianca R.
Santos, Kelem Costa dos
Medeiros, Benedito Junior Lima de
Sousa, Pergentino Jose da Cunha
Perazzo, Fábio Ferreira [UNIFESP]
Carvalho, José Carlos Tavares
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Amapá Laboratório de Pesquisa em Fármacos
Universidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências Farmacêuticas
Universidade Federal do Pará Faculdade de Farmácia Laboratório de Farmacodinâmica
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Favacho, Hugo Alexandre Silva
Oliveira, Bianca R.
Santos, Kelem Costa dos
Medeiros, Benedito Junior Lima de
Sousa, Pergentino Jose da Cunha
Perazzo, Fábio Ferreira [UNIFESP]
Carvalho, José Carlos Tavares
dc.subject.por.fl_str_mv Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
topic Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
description The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
2015-06-14T13:42:54Z
2015-06-14T13:42:54Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-695X2011005000007
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011.
10.1590/S0102-695X2011005000007
S0102-695X2011000100018.pdf
0102-695X
S0102-695X2011000100018
http://repositorio.unifesp.br/handle/11600/6279
WOS:000289152900018
url http://dx.doi.org/10.1590/S0102-695X2011005000007
http://repositorio.unifesp.br/handle/11600/6279
identifier_str_mv Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011.
10.1590/S0102-695X2011005000007
S0102-695X2011000100018.pdf
0102-695X
S0102-695X2011000100018
WOS:000289152900018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Farmacognosia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 105-114
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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