Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-695X2011005000007 http://repositorio.unifesp.br/handle/11600/6279 |
Resumo: | The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition. |
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Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oilEuterpe oleracea Mart.oilaçaí berryinflammatorynociceptiveArecaceaeThe oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.Universidade Federal do Amapá Laboratório de Pesquisa em FármacosUniversidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências FarmacêuticasUniversidade Federal do Pará Faculdade de Farmácia Laboratório de FarmacodinâmicaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraUNIFESP, Depto. de Ciências Exatas e da TerraSciELOSociedade Brasileira de FarmacognosiaUniversidade Federal do Amapá Laboratório de Pesquisa em FármacosUniversidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências FarmacêuticasUniversidade Federal do Pará Faculdade de Farmácia Laboratório de FarmacodinâmicaUniversidade Federal de São Paulo (UNIFESP)Favacho, Hugo Alexandre SilvaOliveira, Bianca R.Santos, Kelem Costa dosMedeiros, Benedito Junior Lima deSousa, Pergentino Jose da CunhaPerazzo, Fábio Ferreira [UNIFESP]Carvalho, José Carlos Tavares2015-06-14T13:42:54Z2015-06-14T13:42:54Z2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion105-114application/pdfhttp://dx.doi.org/10.1590/S0102-695X2011005000007Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011.10.1590/S0102-695X2011005000007S0102-695X2011000100018.pdf0102-695XS0102-695X2011000100018http://repositorio.unifesp.br/handle/11600/6279WOS:000289152900018engRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T19:35:34Zoai:repositorio.unifesp.br/:11600/6279Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T19:35:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
title |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
spellingShingle |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil Favacho, Hugo Alexandre Silva Euterpe oleracea Mart. oil açaí berry inflammatory nociceptive Arecaceae |
title_short |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
title_full |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
title_fullStr |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
title_full_unstemmed |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
title_sort |
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil |
author |
Favacho, Hugo Alexandre Silva |
author_facet |
Favacho, Hugo Alexandre Silva Oliveira, Bianca R. Santos, Kelem Costa dos Medeiros, Benedito Junior Lima de Sousa, Pergentino Jose da Cunha Perazzo, Fábio Ferreira [UNIFESP] Carvalho, José Carlos Tavares |
author_role |
author |
author2 |
Oliveira, Bianca R. Santos, Kelem Costa dos Medeiros, Benedito Junior Lima de Sousa, Pergentino Jose da Cunha Perazzo, Fábio Ferreira [UNIFESP] Carvalho, José Carlos Tavares |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Amapá Laboratório de Pesquisa em Fármacos Universidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências Farmacêuticas Universidade Federal do Pará Faculdade de Farmácia Laboratório de Farmacodinâmica Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Favacho, Hugo Alexandre Silva Oliveira, Bianca R. Santos, Kelem Costa dos Medeiros, Benedito Junior Lima de Sousa, Pergentino Jose da Cunha Perazzo, Fábio Ferreira [UNIFESP] Carvalho, José Carlos Tavares |
dc.subject.por.fl_str_mv |
Euterpe oleracea Mart. oil açaí berry inflammatory nociceptive Arecaceae |
topic |
Euterpe oleracea Mart. oil açaí berry inflammatory nociceptive Arecaceae |
description |
The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 2015-06-14T13:42:54Z 2015-06-14T13:42:54Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-695X2011005000007 Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011. 10.1590/S0102-695X2011005000007 S0102-695X2011000100018.pdf 0102-695X S0102-695X2011000100018 http://repositorio.unifesp.br/handle/11600/6279 WOS:000289152900018 |
url |
http://dx.doi.org/10.1590/S0102-695X2011005000007 http://repositorio.unifesp.br/handle/11600/6279 |
identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011. 10.1590/S0102-695X2011005000007 S0102-695X2011000100018.pdf 0102-695X S0102-695X2011000100018 WOS:000289152900018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Farmacognosia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
105-114 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268381591764992 |