Antischistosomal activity from Brazilian marine algae
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663 |
Resumo: | Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed. |
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Antischistosomal activity from Brazilian marine algaeAntischistosomalSeaweedsSecondary metabolitesSchistosoma mansoniTerpenesAbstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed.Sociedade Brasileira de Farmacognosia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663Revista Brasileira de Farmacognosia v.25 n.6 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.09.005info:eu-repo/semantics/openAccessStein,Erika M.Machado,Levi P.Roffato,Henrique K.Miyasato,Patricia A.Nakano,ElianaColepicolo,PioAndreguetti,Daniel X.eng2015-12-22T00:00:00Zoai:scielo:S0102-695X2015000600663Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-12-22T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Antischistosomal activity from Brazilian marine algae |
title |
Antischistosomal activity from Brazilian marine algae |
spellingShingle |
Antischistosomal activity from Brazilian marine algae Stein,Erika M. Antischistosomal Seaweeds Secondary metabolites Schistosoma mansoni Terpenes |
title_short |
Antischistosomal activity from Brazilian marine algae |
title_full |
Antischistosomal activity from Brazilian marine algae |
title_fullStr |
Antischistosomal activity from Brazilian marine algae |
title_full_unstemmed |
Antischistosomal activity from Brazilian marine algae |
title_sort |
Antischistosomal activity from Brazilian marine algae |
author |
Stein,Erika M. |
author_facet |
Stein,Erika M. Machado,Levi P. Roffato,Henrique K. Miyasato,Patricia A. Nakano,Eliana Colepicolo,Pio Andreguetti,Daniel X. |
author_role |
author |
author2 |
Machado,Levi P. Roffato,Henrique K. Miyasato,Patricia A. Nakano,Eliana Colepicolo,Pio Andreguetti,Daniel X. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Stein,Erika M. Machado,Levi P. Roffato,Henrique K. Miyasato,Patricia A. Nakano,Eliana Colepicolo,Pio Andreguetti,Daniel X. |
dc.subject.por.fl_str_mv |
Antischistosomal Seaweeds Secondary metabolites Schistosoma mansoni Terpenes |
topic |
Antischistosomal Seaweeds Secondary metabolites Schistosoma mansoni Terpenes |
description |
Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.09.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.6 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122469655773184 |