Antischistosomal activity from Brazilian marine algae

Detalhes bibliográficos
Autor(a) principal: Stein,Erika M.
Data de Publicação: 2015
Outros Autores: Machado,Levi P., Roffato,Henrique K., Miyasato,Patricia A., Nakano,Eliana, Colepicolo,Pio, Andreguetti,Daniel X.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663
Resumo: Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed.
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spelling Antischistosomal activity from Brazilian marine algaeAntischistosomalSeaweedsSecondary metabolitesSchistosoma mansoniTerpenesAbstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed.Sociedade Brasileira de Farmacognosia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663Revista Brasileira de Farmacognosia v.25 n.6 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.09.005info:eu-repo/semantics/openAccessStein,Erika M.Machado,Levi P.Roffato,Henrique K.Miyasato,Patricia A.Nakano,ElianaColepicolo,PioAndreguetti,Daniel X.eng2015-12-22T00:00:00Zoai:scielo:S0102-695X2015000600663Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-12-22T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antischistosomal activity from Brazilian marine algae
title Antischistosomal activity from Brazilian marine algae
spellingShingle Antischistosomal activity from Brazilian marine algae
Stein,Erika M.
Antischistosomal
Seaweeds
Secondary metabolites
Schistosoma mansoni
Terpenes
title_short Antischistosomal activity from Brazilian marine algae
title_full Antischistosomal activity from Brazilian marine algae
title_fullStr Antischistosomal activity from Brazilian marine algae
title_full_unstemmed Antischistosomal activity from Brazilian marine algae
title_sort Antischistosomal activity from Brazilian marine algae
author Stein,Erika M.
author_facet Stein,Erika M.
Machado,Levi P.
Roffato,Henrique K.
Miyasato,Patricia A.
Nakano,Eliana
Colepicolo,Pio
Andreguetti,Daniel X.
author_role author
author2 Machado,Levi P.
Roffato,Henrique K.
Miyasato,Patricia A.
Nakano,Eliana
Colepicolo,Pio
Andreguetti,Daniel X.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Stein,Erika M.
Machado,Levi P.
Roffato,Henrique K.
Miyasato,Patricia A.
Nakano,Eliana
Colepicolo,Pio
Andreguetti,Daniel X.
dc.subject.por.fl_str_mv Antischistosomal
Seaweeds
Secondary metabolites
Schistosoma mansoni
Terpenes
topic Antischistosomal
Seaweeds
Secondary metabolites
Schistosoma mansoni
Terpenes
description Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600663
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2015.09.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.25 n.6 2015
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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