Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus

Detalhes bibliográficos
Autor(a) principal: Pinto,Ana Maria Viana
Data de Publicação: 2012
Outros Autores: Leite,José Paulo G., Ferreira,Wilton J., Cavalcanti,Diana N., Villaça,Roberto C., Giongo,Viveca, Teixeira,Valéria L., Paixão,Izabel Christina Nunes de Palmer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400016
Resumo: Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma-3,14-diene-1,17-dial (DA, 2), 10,18-diacetoxy-8-hydroxy-2,6-dolabelladiene (DB1, 3) and 8,10,18-trihydroxy-2,6-dolabelladiene (DB3, 4). The screening to evaluate the cytotoxicity of compounds did not show toxic effects to MDBK cells. The antiviral activity of the compounds was measured by the inhibition of the cytopathic effect on infected cells by plaque assay (PA) and EC50 values were calculated for CAV (EC=2,0± 5.8), DA (EC 2,8± 7.7), DB1 (EC 2,0±9.7), and DB3 (EC 2,3±7.4). Acyclovir (EC50 322± 5.9) was used in all experiments as the control standard. Although the results of the antiviral activity suggest that all compounds are promising as antiviral agents against BVDV, the Selectivity Index suggests that DB1 is the safest of the compounds tested.
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spelling Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virusBVDVantiviralcaulerpinditerpenesmarine algaeCaulerpaDictyotaBovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma-3,14-diene-1,17-dial (DA, 2), 10,18-diacetoxy-8-hydroxy-2,6-dolabelladiene (DB1, 3) and 8,10,18-trihydroxy-2,6-dolabelladiene (DB3, 4). The screening to evaluate the cytotoxicity of compounds did not show toxic effects to MDBK cells. The antiviral activity of the compounds was measured by the inhibition of the cytopathic effect on infected cells by plaque assay (PA) and EC50 values were calculated for CAV (EC=2,0± 5.8), DA (EC 2,8± 7.7), DB1 (EC 2,0±9.7), and DB3 (EC 2,3±7.4). Acyclovir (EC50 322± 5.9) was used in all experiments as the control standard. Although the results of the antiviral activity suggest that all compounds are promising as antiviral agents against BVDV, the Selectivity Index suggests that DB1 is the safest of the compounds tested.Sociedade Brasileira de Farmacognosia2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400016Revista Brasileira de Farmacognosia v.22 n.4 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000060info:eu-repo/semantics/openAccessPinto,Ana Maria VianaLeite,José Paulo G.Ferreira,Wilton J.Cavalcanti,Diana N.Villaça,Roberto C.Giongo,VivecaTeixeira,Valéria L.Paixão,Izabel Christina Nunes de Palmereng2012-06-27T00:00:00Zoai:scielo:S0102-695X2012000400016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-06-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
title Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
spellingShingle Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
Pinto,Ana Maria Viana
BVDV
antiviral
caulerpin
diterpenes
marine algae
Caulerpa
Dictyota
title_short Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
title_full Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
title_fullStr Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
title_full_unstemmed Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
title_sort Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
author Pinto,Ana Maria Viana
author_facet Pinto,Ana Maria Viana
Leite,José Paulo G.
Ferreira,Wilton J.
Cavalcanti,Diana N.
Villaça,Roberto C.
Giongo,Viveca
Teixeira,Valéria L.
Paixão,Izabel Christina Nunes de Palmer
author_role author
author2 Leite,José Paulo G.
Ferreira,Wilton J.
Cavalcanti,Diana N.
Villaça,Roberto C.
Giongo,Viveca
Teixeira,Valéria L.
Paixão,Izabel Christina Nunes de Palmer
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto,Ana Maria Viana
Leite,José Paulo G.
Ferreira,Wilton J.
Cavalcanti,Diana N.
Villaça,Roberto C.
Giongo,Viveca
Teixeira,Valéria L.
Paixão,Izabel Christina Nunes de Palmer
dc.subject.por.fl_str_mv BVDV
antiviral
caulerpin
diterpenes
marine algae
Caulerpa
Dictyota
topic BVDV
antiviral
caulerpin
diterpenes
marine algae
Caulerpa
Dictyota
description Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma-3,14-diene-1,17-dial (DA, 2), 10,18-diacetoxy-8-hydroxy-2,6-dolabelladiene (DB1, 3) and 8,10,18-trihydroxy-2,6-dolabelladiene (DB3, 4). The screening to evaluate the cytotoxicity of compounds did not show toxic effects to MDBK cells. The antiviral activity of the compounds was measured by the inhibition of the cytopathic effect on infected cells by plaque assay (PA) and EC50 values were calculated for CAV (EC=2,0± 5.8), DA (EC 2,8± 7.7), DB1 (EC 2,0±9.7), and DB3 (EC 2,3±7.4). Acyclovir (EC50 322± 5.9) was used in all experiments as the control standard. Although the results of the antiviral activity suggest that all compounds are promising as antiviral agents against BVDV, the Selectivity Index suggests that DB1 is the safest of the compounds tested.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.4 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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