Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308 |
Resumo: | Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups. |
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Genetics and Molecular Biology |
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Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphismshuman monitoringbuccal micronucleus testpesticidesPON 1DNA repair genesFarm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.Sociedade Brasileira de Genética2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308Genetics and Molecular Biology v.38 n.3 2015reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-475738320140336info:eu-repo/semantics/openAccessAdad,Lúcia Maria de MirandaAndrade,Heloísa Helena Rodrigues deKvitko,KátiaLehmann,MauricioCavalcante,Ana Amélia de Carvalho MeloDihl,Rafael Rodrigueseng2015-12-16T00:00:00Zoai:scielo:S1415-47572015000300308Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2015-12-16T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
title |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
spellingShingle |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms Adad,Lúcia Maria de Miranda human monitoring buccal micronucleus test pesticides PON 1 DNA repair genes |
title_short |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
title_full |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
title_fullStr |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
title_full_unstemmed |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
title_sort |
Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms |
author |
Adad,Lúcia Maria de Miranda |
author_facet |
Adad,Lúcia Maria de Miranda Andrade,Heloísa Helena Rodrigues de Kvitko,Kátia Lehmann,Mauricio Cavalcante,Ana Amélia de Carvalho Melo Dihl,Rafael Rodrigues |
author_role |
author |
author2 |
Andrade,Heloísa Helena Rodrigues de Kvitko,Kátia Lehmann,Mauricio Cavalcante,Ana Amélia de Carvalho Melo Dihl,Rafael Rodrigues |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Adad,Lúcia Maria de Miranda Andrade,Heloísa Helena Rodrigues de Kvitko,Kátia Lehmann,Mauricio Cavalcante,Ana Amélia de Carvalho Melo Dihl,Rafael Rodrigues |
dc.subject.por.fl_str_mv |
human monitoring buccal micronucleus test pesticides PON 1 DNA repair genes |
topic |
human monitoring buccal micronucleus test pesticides PON 1 DNA repair genes |
description |
Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-475738320140336 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.38 n.3 2015 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122386317049856 |