Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms

Detalhes bibliográficos
Autor(a) principal: Adad,Lúcia Maria de Miranda
Data de Publicação: 2015
Outros Autores: Andrade,Heloísa Helena Rodrigues de, Kvitko,Kátia, Lehmann,Mauricio, Cavalcante,Ana Amélia de Carvalho Melo, Dihl,Rafael Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308
Resumo: Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.
id SBG-1_43a474746febe26dffd0c260b224be3f
oai_identifier_str oai:scielo:S1415-47572015000300308
network_acronym_str SBG-1
network_name_str Genetics and Molecular Biology
repository_id_str
spelling Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphismshuman monitoringbuccal micronucleus testpesticidesPON 1DNA repair genesFarm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.Sociedade Brasileira de Genética2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308Genetics and Molecular Biology v.38 n.3 2015reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-475738320140336info:eu-repo/semantics/openAccessAdad,Lúcia Maria de MirandaAndrade,Heloísa Helena Rodrigues deKvitko,KátiaLehmann,MauricioCavalcante,Ana Amélia de Carvalho MeloDihl,Rafael Rodrigueseng2015-12-16T00:00:00Zoai:scielo:S1415-47572015000300308Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2015-12-16T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
title Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
spellingShingle Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
Adad,Lúcia Maria de Miranda
human monitoring
buccal micronucleus test
pesticides
PON 1
DNA repair genes
title_short Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
title_full Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
title_fullStr Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
title_full_unstemmed Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
title_sort Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
author Adad,Lúcia Maria de Miranda
author_facet Adad,Lúcia Maria de Miranda
Andrade,Heloísa Helena Rodrigues de
Kvitko,Kátia
Lehmann,Mauricio
Cavalcante,Ana Amélia de Carvalho Melo
Dihl,Rafael Rodrigues
author_role author
author2 Andrade,Heloísa Helena Rodrigues de
Kvitko,Kátia
Lehmann,Mauricio
Cavalcante,Ana Amélia de Carvalho Melo
Dihl,Rafael Rodrigues
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Adad,Lúcia Maria de Miranda
Andrade,Heloísa Helena Rodrigues de
Kvitko,Kátia
Lehmann,Mauricio
Cavalcante,Ana Amélia de Carvalho Melo
Dihl,Rafael Rodrigues
dc.subject.por.fl_str_mv human monitoring
buccal micronucleus test
pesticides
PON 1
DNA repair genes
topic human monitoring
buccal micronucleus test
pesticides
PON 1
DNA repair genes
description Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300308
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-475738320140336
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.38 n.3 2015
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
_version_ 1752122386317049856