Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/129440 |
Resumo: | Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups. |
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Adad, Lucia Maria de MirandaAndrade, Heloisa Helena Rodrigues deKvitko, KatiaLehmann, MaurícioCavalcante, Ana Amélia de C. MeloDihl, Rafael Rodrigues2015-11-10T02:41:31Z20151415-4757http://hdl.handle.net/10183/129440000974451Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 308-315Teste de micronúcleosReparo do DNAPesticidaHuman monitoringBuccal micronucleus testPesticidesPON 1DNA repair genesOccupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphismsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000974451.pdf000974451.pdfTexto completo (inglês)application/pdf582309http://www.lume.ufrgs.br/bitstream/10183/129440/1/000974451.pdf355daf71c4de7c079fadca1b52d5e621MD51TEXT000974451.pdf.txt000974451.pdf.txtExtracted Texttext/plain33852http://www.lume.ufrgs.br/bitstream/10183/129440/2/000974451.pdf.txt30a23ca0a3ee62adc3bf885d8bb1717bMD52THUMBNAIL000974451.pdf.jpg000974451.pdf.jpgGenerated Thumbnailimage/jpeg1770http://www.lume.ufrgs.br/bitstream/10183/129440/3/000974451.pdf.jpg1a161c372d8a8fe765a6f4ddfba1b1dcMD5310183/1294402019-04-25 02:37:08.354006oai:www.lume.ufrgs.br:10183/129440Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-04-25T05:37:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
title |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
spellingShingle |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms Adad, Lucia Maria de Miranda Teste de micronúcleos Reparo do DNA Pesticida Human monitoring Buccal micronucleus test Pesticides PON 1 DNA repair genes |
title_short |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
title_full |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
title_fullStr |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
title_full_unstemmed |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
title_sort |
Occupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphisms |
author |
Adad, Lucia Maria de Miranda |
author_facet |
Adad, Lucia Maria de Miranda Andrade, Heloisa Helena Rodrigues de Kvitko, Katia Lehmann, Maurício Cavalcante, Ana Amélia de C. Melo Dihl, Rafael Rodrigues |
author_role |
author |
author2 |
Andrade, Heloisa Helena Rodrigues de Kvitko, Katia Lehmann, Maurício Cavalcante, Ana Amélia de C. Melo Dihl, Rafael Rodrigues |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Adad, Lucia Maria de Miranda Andrade, Heloisa Helena Rodrigues de Kvitko, Katia Lehmann, Maurício Cavalcante, Ana Amélia de C. Melo Dihl, Rafael Rodrigues |
dc.subject.por.fl_str_mv |
Teste de micronúcleos Reparo do DNA Pesticida |
topic |
Teste de micronúcleos Reparo do DNA Pesticida Human monitoring Buccal micronucleus test Pesticides PON 1 DNA repair genes |
dc.subject.eng.fl_str_mv |
Human monitoring Buccal micronucleus test Pesticides PON 1 DNA repair genes |
description |
Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-11-10T02:41:31Z |
dc.date.issued.fl_str_mv |
2015 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/129440 |
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1415-4757 |
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000974451 |
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http://hdl.handle.net/10183/129440 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 308-315 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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