Underrated Staphylococcus species and their role in antimicrobial resistance spreading
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000300303 |
Resumo: | Abstract The increasing threat of antimicrobial resistance has shed light on the interconnection between humans, animals, the environment, and their roles in the exchange and spreading of resistance genes. In this review, we present evidences that show that Staphylococcus species, usually referred to as harmless or opportunistic pathogens, represent a threat to human and animal health for acting as reservoirs of antimicrobial resistance genes. The capacity of genetic exchange between isolates of different sources and species of the Staphylococcus genus is discussed with emphasis on mobile genetic elements, the contribution of biofilm formation, and evidences obtained either experimentally or through genome analyses. We also discuss the involvement of CRISPR-Cas systems in the limitation of horizontal gene transfer and its suitability as a molecular clock to describe the history of genetic exchange between staphylococci. |
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Genetics and Molecular Biology |
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Underrated Staphylococcus species and their role in antimicrobial resistance spreadingHorizontal gene transferantimicrobial resistancecoagulase negative staphylococcusbiofilmCRISPROne HealthAbstract The increasing threat of antimicrobial resistance has shed light on the interconnection between humans, animals, the environment, and their roles in the exchange and spreading of resistance genes. In this review, we present evidences that show that Staphylococcus species, usually referred to as harmless or opportunistic pathogens, represent a threat to human and animal health for acting as reservoirs of antimicrobial resistance genes. The capacity of genetic exchange between isolates of different sources and species of the Staphylococcus genus is discussed with emphasis on mobile genetic elements, the contribution of biofilm formation, and evidences obtained either experimentally or through genome analyses. We also discuss the involvement of CRISPR-Cas systems in the limitation of horizontal gene transfer and its suitability as a molecular clock to describe the history of genetic exchange between staphylococci.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000300303Genetics and Molecular Biology v.43 n.1 suppl.2 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2019-0065info:eu-repo/semantics/openAccessRossi,Ciro CésarPereira,Monalessa FábiaGiambiagi-deMarval,Marciaeng2020-02-07T00:00:00Zoai:scielo:S1415-47572020000300303Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-02-07T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
title |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
spellingShingle |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading Rossi,Ciro César Horizontal gene transfer antimicrobial resistance coagulase negative staphylococcus biofilm CRISPR One Health |
title_short |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
title_full |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
title_fullStr |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
title_full_unstemmed |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
title_sort |
Underrated Staphylococcus species and their role in antimicrobial resistance spreading |
author |
Rossi,Ciro César |
author_facet |
Rossi,Ciro César Pereira,Monalessa Fábia Giambiagi-deMarval,Marcia |
author_role |
author |
author2 |
Pereira,Monalessa Fábia Giambiagi-deMarval,Marcia |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Rossi,Ciro César Pereira,Monalessa Fábia Giambiagi-deMarval,Marcia |
dc.subject.por.fl_str_mv |
Horizontal gene transfer antimicrobial resistance coagulase negative staphylococcus biofilm CRISPR One Health |
topic |
Horizontal gene transfer antimicrobial resistance coagulase negative staphylococcus biofilm CRISPR One Health |
description |
Abstract The increasing threat of antimicrobial resistance has shed light on the interconnection between humans, animals, the environment, and their roles in the exchange and spreading of resistance genes. In this review, we present evidences that show that Staphylococcus species, usually referred to as harmless or opportunistic pathogens, represent a threat to human and animal health for acting as reservoirs of antimicrobial resistance genes. The capacity of genetic exchange between isolates of different sources and species of the Staphylococcus genus is discussed with emphasis on mobile genetic elements, the contribution of biofilm formation, and evidences obtained either experimentally or through genome analyses. We also discuss the involvement of CRISPR-Cas systems in the limitation of horizontal gene transfer and its suitability as a molecular clock to describe the history of genetic exchange between staphylococci. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000300303 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000300303 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2019-0065 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.43 n.1 suppl.2 2020 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122389735407616 |