Extreme phenotypes approach to investigate host genetics and COVID-19 outcomes

• Autor(a) principal: Naslavsky,Michel Satya
• Data de Publicação: 2021
• Outros Autores: Vidigal,Mateus, Matos,Larissa do Rêgo Barros, Cória,Vivian Romanholi, Batista Junior,Pedro Benedito, Razuk,Álvaro, Saldiva,Paulo Hilário Nascimento, Dolhnikoff,Marisa, Schidlowski,Laire, Prando,Carolina, Cunha-Neto,Edécio, Condino-Neto,Antonio, Passos-Bueno,Maria Rita, Zatz,Mayana
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Genetics and Molecular Biology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200307
• topic: COVID-19; host genetics; extreme phenotypes; infectious disease

Abstract COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject’s ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes.