Host genetics and population structure effects on parasitic disease

Detalhes bibliográficos
Autor(a) principal: Blangero, Sarah Williams
Data de Publicação: 2012
Outros Autores: Criscione, Charles D., VandeBerg, John L., Oliveira, Rodrigo Corrêa de, Williams, Kimberly D., Subedi, Janardan, Kent Jr., Jack W., Williams, Jeff, Kumar, Satish, Blangero, John
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7996
Resumo: Texas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USA
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spelling Blangero, Sarah WilliamsCriscione, Charles D.VandeBerg, John L.Oliveira, Rodrigo Corrêa deWilliams, Kimberly D.Subedi, JanardanKent Jr., Jack W.Williams, JeffKumar, SatishBlangero, John2014-07-18T14:37:13Z2014-07-18T14:37:13Z2012WILLIAMS-BLANGERO, Sarah et al. Host genetics and population structure effects on parasitic disease. Philosophical Transactions of the Royal Society. 2012, vol. 367, pp. 887-894.0962-8436https://www.arca.fiocruz.br/handle/icict/799610.1098/rstb.2011.0296engThe Royal SocietyHost genetics and population structure effects on parasitic diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USATexas A&M University. Department of Biology. College Station, TX, USATexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USA/Southwest National Primate Research Center. San Antonio, TX, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilTemple University. Department of Anthropology. Philadelphia, PA, USAMiami University. Department of Sociology and Gerontology. Oxford, OH, USATexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USATexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USATexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USATexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USAHost genetic factors exert significant influences on differential susceptibility to many infectious diseases. In addition, population structure of both host and parasite may influence disease distribution patterns. In this study, we assess the effects of population structure on infectious disease in two populations in which host genetic factors influencing susceptibility to parasitic disease have been extensively studied. The first population is the Jirel population of eastern Nepal that has been the subject of research on the determinants of differential susceptibility to soil-transmitted helminth infections. The second group is a Brazilian population residing in an area endemic for Trypanosoma cruzi infection that has been assessed for genetic influences on differential disease progression in Chagas disease. For measures of Ascaris worm burden, within-population host genetic effects are generally more important than host population structure factors in determining patterns of infectious disease. No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found.population structuregenetics of infectious disease susceptibilityintestinal wormsChagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALHost genetics and population structure effects on parasitic disease.pdfHost genetics and population structure effects on parasitic disease.pdfapplication/pdf140806https://www.arca.fiocruz.br/bitstream/icict/7996/1/Host%20genetics%20and%20population%20structure%20effects%20on%20parasitic%20disease.pdf74acfe3a95e5eaea8c268da026e37fdbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7996/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTHost genetics and population structure effects on parasitic disease.pdf.txtHost genetics and population structure effects on parasitic disease.pdf.txtExtracted texttext/plain41489https://www.arca.fiocruz.br/bitstream/icict/7996/3/Host%20genetics%20and%20population%20structure%20effects%20on%20parasitic%20disease.pdf.txt1d879e8723f34ebf2d3b3f107e08643fMD53icict/79962018-04-06 08:48:45.394oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:48:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Host genetics and population structure effects on parasitic disease
title Host genetics and population structure effects on parasitic disease
spellingShingle Host genetics and population structure effects on parasitic disease
Blangero, Sarah Williams
population structure
genetics of infectious disease susceptibility
intestinal worms
Chagas disease
title_short Host genetics and population structure effects on parasitic disease
title_full Host genetics and population structure effects on parasitic disease
title_fullStr Host genetics and population structure effects on parasitic disease
title_full_unstemmed Host genetics and population structure effects on parasitic disease
title_sort Host genetics and population structure effects on parasitic disease
author Blangero, Sarah Williams
author_facet Blangero, Sarah Williams
Criscione, Charles D.
VandeBerg, John L.
Oliveira, Rodrigo Corrêa de
Williams, Kimberly D.
Subedi, Janardan
Kent Jr., Jack W.
Williams, Jeff
Kumar, Satish
Blangero, John
author_role author
author2 Criscione, Charles D.
VandeBerg, John L.
Oliveira, Rodrigo Corrêa de
Williams, Kimberly D.
Subedi, Janardan
Kent Jr., Jack W.
Williams, Jeff
Kumar, Satish
Blangero, John
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Blangero, Sarah Williams
Criscione, Charles D.
VandeBerg, John L.
Oliveira, Rodrigo Corrêa de
Williams, Kimberly D.
Subedi, Janardan
Kent Jr., Jack W.
Williams, Jeff
Kumar, Satish
Blangero, John
dc.subject.en.pt_BR.fl_str_mv population structure
genetics of infectious disease susceptibility
intestinal worms
Chagas disease
topic population structure
genetics of infectious disease susceptibility
intestinal worms
Chagas disease
description Texas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USA
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-18T14:37:13Z
dc.date.available.fl_str_mv 2014-07-18T14:37:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WILLIAMS-BLANGERO, Sarah et al. Host genetics and population structure effects on parasitic disease. Philosophical Transactions of the Royal Society. 2012, vol. 367, pp. 887-894.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7996
dc.identifier.issn.none.fl_str_mv 0962-8436
dc.identifier.doi.none.fl_str_mv 10.1098/rstb.2011.0296
identifier_str_mv WILLIAMS-BLANGERO, Sarah et al. Host genetics and population structure effects on parasitic disease. Philosophical Transactions of the Royal Society. 2012, vol. 367, pp. 887-894.
0962-8436
10.1098/rstb.2011.0296
url https://www.arca.fiocruz.br/handle/icict/7996
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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