Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Genetics and Molecular Biology |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400600 |
Resumo: | Abstract Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association between MBL2 polymorphism related to low production of serum MBL and the frequency of vasoocclusive events (FVOE) in children ≤ 5 years old with SCA (p = 0.0229; OR 5.55; CI 1.11-27.66). Further studies are needed to explore the role of low MBL2 in the pathophysiology of vasoocclusive events in SCA. |
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Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemiaMBL2polymorphismsickle cell anemiavaso-occlusive eventsAbstract Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association between MBL2 polymorphism related to low production of serum MBL and the frequency of vasoocclusive events (FVOE) in children ≤ 5 years old with SCA (p = 0.0229; OR 5.55; CI 1.11-27.66). Further studies are needed to explore the role of low MBL2 in the pathophysiology of vasoocclusive events in SCA.Sociedade Brasileira de Genética2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400600Genetics and Molecular Biology v.40 n.3 2017reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2016-0161info:eu-repo/semantics/openAccessMedeiros,Fernanda SilvaMendonça,Taciana Furtado deLopes,Katiuscia Araújo de MirandaFrança,Laís Medeiros da CâmaraSilva,Andreia Soares daVasconcelos,Luydson Richardson SilvaOliveira,Maria do Carmo Valgueiro Costa deAnjos,Ana Cláudia Mendonça dosHatzlhofer,Betânia Lucena DominguesBezerra,Marcos André CavalcantiAraújo,Aderson da SilvaMoura,PatríciaCavalcanti,Maria do Socorro de Mendonçaeng2017-09-01T00:00:00Zoai:scielo:S1415-47572017000400600Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2017-09-01T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
| dc.title.none.fl_str_mv |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| title |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| spellingShingle |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia Medeiros,Fernanda Silva MBL2 polymorphism sickle cell anemia vaso-occlusive events |
| title_short |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| title_full |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| title_fullStr |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| title_full_unstemmed |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| title_sort |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia |
| author |
Medeiros,Fernanda Silva |
| author_facet |
Medeiros,Fernanda Silva Mendonça,Taciana Furtado de Lopes,Katiuscia Araújo de Miranda França,Laís Medeiros da Câmara Silva,Andreia Soares da Vasconcelos,Luydson Richardson Silva Oliveira,Maria do Carmo Valgueiro Costa de Anjos,Ana Cláudia Mendonça dos Hatzlhofer,Betânia Lucena Domingues Bezerra,Marcos André Cavalcanti Araújo,Aderson da Silva Moura,Patrícia Cavalcanti,Maria do Socorro de Mendonça |
| author_role |
author |
| author2 |
Mendonça,Taciana Furtado de Lopes,Katiuscia Araújo de Miranda França,Laís Medeiros da Câmara Silva,Andreia Soares da Vasconcelos,Luydson Richardson Silva Oliveira,Maria do Carmo Valgueiro Costa de Anjos,Ana Cláudia Mendonça dos Hatzlhofer,Betânia Lucena Domingues Bezerra,Marcos André Cavalcanti Araújo,Aderson da Silva Moura,Patrícia Cavalcanti,Maria do Socorro de Mendonça |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Medeiros,Fernanda Silva Mendonça,Taciana Furtado de Lopes,Katiuscia Araújo de Miranda França,Laís Medeiros da Câmara Silva,Andreia Soares da Vasconcelos,Luydson Richardson Silva Oliveira,Maria do Carmo Valgueiro Costa de Anjos,Ana Cláudia Mendonça dos Hatzlhofer,Betânia Lucena Domingues Bezerra,Marcos André Cavalcanti Araújo,Aderson da Silva Moura,Patrícia Cavalcanti,Maria do Socorro de Mendonça |
| dc.subject.por.fl_str_mv |
MBL2 polymorphism sickle cell anemia vaso-occlusive events |
| topic |
MBL2 polymorphism sickle cell anemia vaso-occlusive events |
| description |
Abstract Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association between MBL2 polymorphism related to low production of serum MBL and the frequency of vasoocclusive events (FVOE) in children ≤ 5 years old with SCA (p = 0.0229; OR 5.55; CI 1.11-27.66). Further studies are needed to explore the role of low MBL2 in the pathophysiology of vasoocclusive events in SCA. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-09-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400600 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400600 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2016-0161 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
| dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.40 n.3 2017 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
| instname_str |
Sociedade Brasileira de Genética (SBG) |
| instacron_str |
SBG |
| institution |
SBG |
| reponame_str |
Genetics and Molecular Biology |
| collection |
Genetics and Molecular Biology |
| repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
| repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122387627769856 |