Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease

Detalhes bibliográficos
Autor(a) principal: Gonçalves, M. S.
Data de Publicação: 2001
Outros Autores: Queiroz, I. L., Cardoso, S. A., Zanetti, A., Strapazoni, A. C., Adorno, Elisângela Vitória, Albuquerque, Arlete Barreto Lins de, Santana, Ademir Eugênio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7630
Resumo: p. 1309-1313
id UFBA-2_d81df34ef2be333341bbd373d816f2d9
oai_identifier_str oai:repositorio.ufba.br:ri/7630
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Gonçalves, M. S.Queiroz, I. L.Cardoso, S. A.Zanetti, A.Strapazoni, A. C.Adorno, Elisângela VitóriaAlbuquerque, Arlete Barreto Lins deSantana, Ademir Eugênio deGonçalves, M. S.Queiroz, I. L.Cardoso, S. A.Zanetti, A.Strapazoni, A. C.Adorno, Elisângela VitóriaAlbuquerque, Arlete Barreto Lins deSantana, Ademir Eugênio de2012-12-17T19:11:18Z2012-12-17T19:11:18Z20010100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/7630v. 34, n. 10p. 1309-1313Sickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are unknown. The increase of the chemotactic factor interleukin 8 (IL-8) has been reported to be involved in sickle cell disease crisis, but this has not been demonstrated conclusively. In the present study we analyzed serum IL-8 levels by ELISA and hematological parameters and hemoglobin patterns by standard techniques in 23 (21 SS and 2 SC) Brazilian patients with sickle cell syndromes during VOC caused by different inducing factors, 22 (21 SS and 1 SC) sickle cell patients out of crisis, and 11 healthy controls. Increased IL-8 levels were observed in 19 of 23 VOC patients (79.2%), 3 of them with more than 1,000 pg/ml. Seventeen of 22 (77.3%) non-crisis patients showed low IL-8 levels (less than 15 pg/ml). Healthy controls had low IL-8 levels. A significant difference in serum IL-8 levels was observed between crisis and non-crisis sickle cell patients (P<0.0001). There was no correlation between IL-8 levels and hematological data or hemoglobin patterns. High serum IL-8 levels were observed in VOC patients independently of the crisis-inducing factor. We conclude that in the studied population, IL-8 concentration may be a useful VOC marker, although the mechanism of the pathogenic process of sickle cell VOC syndromes remains unclear.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-17T19:11:18Z No. of bitstreams: 1 4226.pdf: 152416 bytes, checksum: 512aa64419dd6e1503998984ac84211d (MD5)Made available in DSpace on 2012-12-17T19:11:18Z (GMT). No. of bitstreams: 1 4226.pdf: 152416 bytes, checksum: 512aa64419dd6e1503998984ac84211d (MD5) Previous issue date: 2001http://dx.doi.org/10.1590/S0100-879X2001001000011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinterleukin 8sickle cell syndromesvaso-occlusive crisisInterleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell diseaseBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL4226.pdf4226.pdfapplication/pdf152416https://repositorio.ufba.br/bitstream/ri/7630/1/4226.pdf512aa64419dd6e1503998984ac84211dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7630/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT4226.pdf.txt4226.pdf.txtExtracted texttext/plain21032https://repositorio.ufba.br/bitstream/ri/7630/3/4226.pdf.txt4ca587b15a0a0e3f8805e1550c928258MD53ri/76302022-08-08 13:18:12.735oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:12Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
spellingShingle Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
Gonçalves, M. S.
interleukin 8
sickle cell syndromes
vaso-occlusive crisis
title_short Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_full Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_fullStr Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_full_unstemmed Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_sort Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
author Gonçalves, M. S.
author_facet Gonçalves, M. S.
Queiroz, I. L.
Cardoso, S. A.
Zanetti, A.
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Santana, Ademir Eugênio de
author_role author
author2 Queiroz, I. L.
Cardoso, S. A.
Zanetti, A.
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Santana, Ademir Eugênio de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, M. S.
Queiroz, I. L.
Cardoso, S. A.
Zanetti, A.
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Santana, Ademir Eugênio de
Gonçalves, M. S.
Queiroz, I. L.
Cardoso, S. A.
Zanetti, A.
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Santana, Ademir Eugênio de
dc.subject.por.fl_str_mv interleukin 8
sickle cell syndromes
vaso-occlusive crisis
topic interleukin 8
sickle cell syndromes
vaso-occlusive crisis
description p. 1309-1313
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-12-17T19:11:18Z
dc.date.available.fl_str_mv 2012-12-17T19:11:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7630
dc.identifier.issn.none.fl_str_mv 0100-879X
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 10
identifier_str_mv 0100-879X
v. 34, n. 10
url http://www.repositorio.ufba.br/ri/handle/ri/7630
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2001001000011
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/7630/1/4226.pdf
https://repositorio.ufba.br/bitstream/ri/7630/2/license.txt
https://repositorio.ufba.br/bitstream/ri/7630/3/4226.pdf.txt
bitstream.checksum.fl_str_mv 512aa64419dd6e1503998984ac84211d
1b89a9a0548218172d7c829f87a0eab9
4ca587b15a0a0e3f8805e1550c928258
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459413367816192

Registros relacionados