Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37113 |
Resumo: | FACEPE |
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Farias, Isabela Cristina CordeiroBelmont, Taciana Furtado de MendonçaSilva, Andreia Soares daÓ, Kleyton Palmeira doFerreira, Felipe Roberto BorbaMedeiros, Fernanda SilvaVasconcelos, Luydson Richardson SilvaBezerra, Marcos Andre CavalcantiAraújo, Aderson da SilvaMoura, Patrícia Muniz Mendes Freire deHatzlhofer, Betânia Lucena DominguesAnjos, Ana Cláudia Mendonça dosCavalcanti, Maria do Socorro de Mendonça2019-11-18T13:55:11Z2019-11-18T13:55:11Z2018FARIAS, Isabela Cristina Cordeiro et al. Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia. Mediterranean Journal of Hematology and Infectious Diseases, v. 10, p. 1-5, 21 Feb. 2018.2035-3006https://www.arca.fiocruz.br/handle/icict/3711310.4084/MJHID.2018.012FACEPEUniversidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil / Universidade Federal Rural de Pernambuco. Programa de Pós-Graduação em Biotecnologia. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil / Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil.Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil / Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil.The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS.engPAGEpressAssociation of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMnSODSickle cell anemiaVaso-occlusive eventsSuperóxido DismutaseAnemia Falciformeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/37113/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALAssociation of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.pdfAssociation of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.pdfapplication/pdf335007https://www.arca.fiocruz.br/bitstream/icict/37113/2/Association%20of%20the%20SOD2%20Polymorphism%20%28Val16Ala%29%20and%20SOD%20Activity%20with%20Vaso-occlusive%20Crisis%20and%20Acute%20Splenic%20Sequestration%20in%20Children%20with%20Sickle%20Cell%20Anemia.pdfa614766bb4931821c7294ae8bbbed5e6MD52TEXTAssociation of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.pdf.txtAssociation of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.pdf.txtExtracted 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| dc.title.en.fl_str_mv |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| spellingShingle |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia Farias, Isabela Cristina Cordeiro MnSOD Sickle cell anemia Vaso-occlusive events Superóxido Dismutase Anemia Falciforme |
| title_short |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_full |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_fullStr |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_full_unstemmed |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_sort |
Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia |
| author |
Farias, Isabela Cristina Cordeiro |
| author_facet |
Farias, Isabela Cristina Cordeiro Belmont, Taciana Furtado de Mendonça Silva, Andreia Soares da Ó, Kleyton Palmeira do Ferreira, Felipe Roberto Borba Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Bezerra, Marcos Andre Cavalcanti Araújo, Aderson da Silva Moura, Patrícia Muniz Mendes Freire de Hatzlhofer, Betânia Lucena Domingues Anjos, Ana Cláudia Mendonça dos Cavalcanti, Maria do Socorro de Mendonça |
| author_role |
author |
| author2 |
Belmont, Taciana Furtado de Mendonça Silva, Andreia Soares da Ó, Kleyton Palmeira do Ferreira, Felipe Roberto Borba Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Bezerra, Marcos Andre Cavalcanti Araújo, Aderson da Silva Moura, Patrícia Muniz Mendes Freire de Hatzlhofer, Betânia Lucena Domingues Anjos, Ana Cláudia Mendonça dos Cavalcanti, Maria do Socorro de Mendonça |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Farias, Isabela Cristina Cordeiro Belmont, Taciana Furtado de Mendonça Silva, Andreia Soares da Ó, Kleyton Palmeira do Ferreira, Felipe Roberto Borba Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Bezerra, Marcos Andre Cavalcanti Araújo, Aderson da Silva Moura, Patrícia Muniz Mendes Freire de Hatzlhofer, Betânia Lucena Domingues Anjos, Ana Cláudia Mendonça dos Cavalcanti, Maria do Socorro de Mendonça |
| dc.subject.en.en.fl_str_mv |
MnSOD Sickle cell anemia Vaso-occlusive events |
| topic |
MnSOD Sickle cell anemia Vaso-occlusive events Superóxido Dismutase Anemia Falciforme |
| dc.subject.decs.pt_BR.fl_str_mv |
Superóxido Dismutase Anemia Falciforme |
| description |
FACEPE |
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2018 |
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2018 |
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2019-11-18T13:55:11Z |
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2019-11-18T13:55:11Z |
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FARIAS, Isabela Cristina Cordeiro et al. Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia. Mediterranean Journal of Hematology and Infectious Diseases, v. 10, p. 1-5, 21 Feb. 2018. |
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https://www.arca.fiocruz.br/handle/icict/37113 |
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2035-3006 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.4084/MJHID.2018.012 |
| identifier_str_mv |
FARIAS, Isabela Cristina Cordeiro et al. Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia. Mediterranean Journal of Hematology and Infectious Diseases, v. 10, p. 1-5, 21 Feb. 2018. 2035-3006 10.4084/MJHID.2018.012 |
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PAGEpress |
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