Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil

Detalhes bibliográficos
Autor(a) principal: Feitosa,Mary Furlan
Data de Publicação: 1999
Outros Autores: Azevêdo,Eliane, Lima,Ângela Maria, Krieger,Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100001
Resumo: A sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.
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spelling Genetic causes involved in Leishmania Chagasi infection innortheastern: BrazilA sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.Sociedade Brasileira de Genética1999-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100001Genetics and Molecular Biology v.22 n.1 1999reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571999000100001info:eu-repo/semantics/openAccessFeitosa,Mary FurlanAzevêdo,ElianeLima,Ângela MariaKrieger,Henriqueeng1999-06-02T00:00:00Zoai:scielo:S1415-47571999000100001Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:1999-06-02T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
title Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
spellingShingle Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
Feitosa,Mary Furlan
title_short Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
title_full Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
title_fullStr Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
title_full_unstemmed Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
title_sort Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
author Feitosa,Mary Furlan
author_facet Feitosa,Mary Furlan
Azevêdo,Eliane
Lima,Ângela Maria
Krieger,Henrique
author_role author
author2 Azevêdo,Eliane
Lima,Ângela Maria
Krieger,Henrique
author2_role author
author
author
dc.contributor.author.fl_str_mv Feitosa,Mary Furlan
Azevêdo,Eliane
Lima,Ângela Maria
Krieger,Henrique
description A sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.
publishDate 1999
dc.date.none.fl_str_mv 1999-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47571999000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.22 n.1 1999
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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instname_str Sociedade Brasileira de Genética (SBG)
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institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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