Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

Detalhes bibliográficos
Autor(a) principal: Brenna, Sylvia Michelina Fernandes
Data de Publicação: 2004
Outros Autores: Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP], Zeferino, Luiz Carlos, Pereira, Julia Santucci [UNIFESP], Martinez, Edson Zachaione, Syrjänen, Kari Juhani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1415-47572004000400005
http://repositorio.unifesp.br/handle/11600/1956
Resumo: The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
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spelling Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancerp53 polymorphismcodon 72genetic polymorphismcervix cancerhuman papillomavirusThe p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.Hospital Maternidade Leonor Mendes de Barros Oncologia GinecológicaUniversidade Federal de São Paulo (UNIFESP) Laboratório de Ginecologia MolecularUniversidade Estadual de Campinas Faculdade de Medicina Oncologia GinecológicaUniversidade de São Paulo Departamento de Medicina Social Faculdade de Medicina de Ribeirão PretoIstituto Superiore di Sanità Laboratory of Epidemiology and Biostatistics Cytopathology UnitUNIFESP, Laboratório de Ginecologia MolecularSciELOSociedade Brasileira de GenéticaHospital Maternidade Leonor Mendes de Barros Oncologia GinecológicaUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Istituto Superiore di Sanità Laboratory of Epidemiology and Biostatistics Cytopathology UnitBrenna, Sylvia Michelina FernandesSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]Zeferino, Luiz CarlosPereira, Julia Santucci [UNIFESP]Martinez, Edson ZachaioneSyrjänen, Kari Juhani2015-06-14T13:30:15Z2015-06-14T13:30:15Z2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion496-499application/pdfhttp://dx.doi.org/10.1590/S1415-47572004000400005Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.10.1590/S1415-47572004000400005S1415-47572004000400005.pdf1415-4757S1415-47572004000400005http://repositorio.unifesp.br/handle/11600/1956WOS:000226583400004engGenetics and Molecular Biologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:20:59Zoai:repositorio.unifesp.br/:11600/1956Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T00:20:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
spellingShingle Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
Brenna, Sylvia Michelina Fernandes
p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
title_short Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_full Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_fullStr Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_full_unstemmed Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_sort Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
author Brenna, Sylvia Michelina Fernandes
author_facet Brenna, Sylvia Michelina Fernandes
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Zeferino, Luiz Carlos
Pereira, Julia Santucci [UNIFESP]
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
author_role author
author2 Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Zeferino, Luiz Carlos
Pereira, Julia Santucci [UNIFESP]
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Hospital Maternidade Leonor Mendes de Barros Oncologia Ginecológica
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Istituto Superiore di Sanità Laboratory of Epidemiology and Biostatistics Cytopathology Unit
dc.contributor.author.fl_str_mv Brenna, Sylvia Michelina Fernandes
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Zeferino, Luiz Carlos
Pereira, Julia Santucci [UNIFESP]
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
dc.subject.por.fl_str_mv p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
topic p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
description The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
2015-06-14T13:30:15Z
2015-06-14T13:30:15Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1415-47572004000400005
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.
10.1590/S1415-47572004000400005
S1415-47572004000400005.pdf
1415-4757
S1415-47572004000400005
http://repositorio.unifesp.br/handle/11600/1956
WOS:000226583400004
url http://dx.doi.org/10.1590/S1415-47572004000400005
http://repositorio.unifesp.br/handle/11600/1956
identifier_str_mv Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.
10.1590/S1415-47572004000400005
S1415-47572004000400005.pdf
1415-4757
S1415-47572004000400005
WOS:000226583400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics and Molecular Biology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 496-499
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268285870407680

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