Immunosenescence
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Geriatrics, Gerontology and Aging (Online) |
Texto Completo: | https://ggaging.com/details/240 |
Resumo: | <p><b>INTRODUCTION:</b> Aging involves various complex cellular and molecular changes, including a general decline in immunological functions known as immunosenescence. The clinical consequences of immunosenescence include increased susceptibility to respiratory infections, neoplasias and cardiovascular diseases.<br> <b>OBJECTIVE:</b> To review the major cellular and molecular changes in immunosenescence.<br> <b>METHODS:</b> Literature review between 1996-2011 employing the PubMed and SciELO databases.<br> <b>RESULTS:</b> With advancing age, the cells of the innate and adaptive immune system exhibit worsening of generalized function and a reduced number of naïve T cells. In addition, there is an expansion of certain clones of T lymphocytes (mainly CD8 +CD28- cells) that correlate with morbidity and mortality in the elderly. Besides the age-related impairments in cellular immune responses, aging is also associated with high serum inflammatory molecules and increased counts of circulating NK cells which is characterized by inflammaging. This framework can contribute to the pathogenesis and pathophysiology of inflammatory diseases such as atherosclerosis, Alzheimer's disease among others. In addition, during immunosenescence is also present a poor response to vaccines and increase in infectious diseases, tumors and autoimmunity.<br> <b>CONCLUSION:</b> Understanding the relationship between the immune system and aging is of great importance to human health particularly on the impact of age-related diseases. It also helps to promote more effective and specific interventions for the elderly diseases.</p> |
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Geriatrics, Gerontology and Aging (Online) |
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ImmunosenescenceAging, immunosenescence.<p><b>INTRODUCTION:</b> Aging involves various complex cellular and molecular changes, including a general decline in immunological functions known as immunosenescence. The clinical consequences of immunosenescence include increased susceptibility to respiratory infections, neoplasias and cardiovascular diseases.<br> <b>OBJECTIVE:</b> To review the major cellular and molecular changes in immunosenescence.<br> <b>METHODS:</b> Literature review between 1996-2011 employing the PubMed and SciELO databases.<br> <b>RESULTS:</b> With advancing age, the cells of the innate and adaptive immune system exhibit worsening of generalized function and a reduced number of naïve T cells. In addition, there is an expansion of certain clones of T lymphocytes (mainly CD8 +CD28- cells) that correlate with morbidity and mortality in the elderly. Besides the age-related impairments in cellular immune responses, aging is also associated with high serum inflammatory molecules and increased counts of circulating NK cells which is characterized by inflammaging. This framework can contribute to the pathogenesis and pathophysiology of inflammatory diseases such as atherosclerosis, Alzheimer's disease among others. In addition, during immunosenescence is also present a poor response to vaccines and increase in infectious diseases, tumors and autoimmunity.<br> <b>CONCLUSION:</b> Understanding the relationship between the immune system and aging is of great importance to human health particularly on the impact of age-related diseases. It also helps to promote more effective and specific interventions for the elderly diseases.</p>Sociedade Brasileira de Geriatria e Gerontologia2011-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttps://ggaging.com/details/240Geriatrics, Gerontology and Aging v.5 n.3 2011reponame:Geriatrics, Gerontology and Aging (Online)instname:Sociedade Brasileira de Geriatria e Gerontologiainstacron:SBGGinfo:eu-repo/semantics/openAccess Torres,Karen Cecília de Lima Pereira,Patrícia de Araújo Lima,Giselle Sabrina França de Souza,Bruno Rezende Miranda,Débora Marques de Bauer,Moisés Evandro Romano-Silva,Marco Aurélioeng2011-07-01T00:00:00Zoai:ggaging.com:240Revistahttp://sbgg.org.br/publicacoes-cientificas/revista-geriatria-gerontologia/ONGhttps://old.scielo.br/oai/scielo-oai.phpexecutiveditors@ggaging.com||nacional@sbgg.org.br2447-21232447-2115opendoar:2011-07-01T00:00Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologiafalse |
dc.title.none.fl_str_mv |
Immunosenescence |
title |
Immunosenescence |
spellingShingle |
Immunosenescence Torres,Karen Cecília de Lima Aging, immunosenescence. |
title_short |
Immunosenescence |
title_full |
Immunosenescence |
title_fullStr |
Immunosenescence |
title_full_unstemmed |
Immunosenescence |
title_sort |
Immunosenescence |
author |
Torres,Karen Cecília de Lima |
author_facet |
Torres,Karen Cecília de Lima Pereira,Patrícia de Araújo Lima,Giselle Sabrina França de Souza,Bruno Rezende Miranda,Débora Marques de Bauer,Moisés Evandro Romano-Silva,Marco Aurélio |
author_role |
author |
author2 |
Pereira,Patrícia de Araújo Lima,Giselle Sabrina França de Souza,Bruno Rezende Miranda,Débora Marques de Bauer,Moisés Evandro Romano-Silva,Marco Aurélio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Torres,Karen Cecília de Lima Pereira,Patrícia de Araújo Lima,Giselle Sabrina França de Souza,Bruno Rezende Miranda,Débora Marques de Bauer,Moisés Evandro Romano-Silva,Marco Aurélio |
dc.subject.por.fl_str_mv |
Aging, immunosenescence. |
topic |
Aging, immunosenescence. |
description |
<p><b>INTRODUCTION:</b> Aging involves various complex cellular and molecular changes, including a general decline in immunological functions known as immunosenescence. The clinical consequences of immunosenescence include increased susceptibility to respiratory infections, neoplasias and cardiovascular diseases.<br> <b>OBJECTIVE:</b> To review the major cellular and molecular changes in immunosenescence.<br> <b>METHODS:</b> Literature review between 1996-2011 employing the PubMed and SciELO databases.<br> <b>RESULTS:</b> With advancing age, the cells of the innate and adaptive immune system exhibit worsening of generalized function and a reduced number of naïve T cells. In addition, there is an expansion of certain clones of T lymphocytes (mainly CD8 +CD28- cells) that correlate with morbidity and mortality in the elderly. Besides the age-related impairments in cellular immune responses, aging is also associated with high serum inflammatory molecules and increased counts of circulating NK cells which is characterized by inflammaging. This framework can contribute to the pathogenesis and pathophysiology of inflammatory diseases such as atherosclerosis, Alzheimer's disease among others. In addition, during immunosenescence is also present a poor response to vaccines and increase in infectious diseases, tumors and autoimmunity.<br> <b>CONCLUSION:</b> Understanding the relationship between the immune system and aging is of great importance to human health particularly on the impact of age-related diseases. It also helps to promote more effective and specific interventions for the elderly diseases.</p> |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ggaging.com/details/240 |
url |
https://ggaging.com/details/240 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
dc.source.none.fl_str_mv |
Geriatrics, Gerontology and Aging v.5 n.3 2011 reponame:Geriatrics, Gerontology and Aging (Online) instname:Sociedade Brasileira de Geriatria e Gerontologia instacron:SBGG |
instname_str |
Sociedade Brasileira de Geriatria e Gerontologia |
instacron_str |
SBGG |
institution |
SBGG |
reponame_str |
Geriatrics, Gerontology and Aging (Online) |
collection |
Geriatrics, Gerontology and Aging (Online) |
repository.name.fl_str_mv |
Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologia |
repository.mail.fl_str_mv |
executiveditors@ggaging.com||nacional@sbgg.org.br |
_version_ |
1797174501298929664 |