Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans

Detalhes bibliográficos
Autor(a) principal: Chiuchetta,Simone Jurema Ruggeri
Data de Publicação: 2002
Outros Autores: Castro-Prado,Marialba Avezum Alves de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014
Resumo: Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells.
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spelling Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulansantineoplastic agentsmitotic crossing-oversecondary malignancesDoxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells.Sociedade Brasileira de Microbiologia2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014Brazilian Journal of Microbiology v.33 n.3 2002reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822002000300014info:eu-repo/semantics/openAccessChiuchetta,Simone Jurema RuggeriCastro-Prado,Marialba Avezum Alves deeng2003-06-23T00:00:00Zoai:scielo:S1517-83822002000300014Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2003-06-23T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
title Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
spellingShingle Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
Chiuchetta,Simone Jurema Ruggeri
antineoplastic agents
mitotic crossing-over
secondary malignances
title_short Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
title_full Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
title_fullStr Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
title_full_unstemmed Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
title_sort Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
author Chiuchetta,Simone Jurema Ruggeri
author_facet Chiuchetta,Simone Jurema Ruggeri
Castro-Prado,Marialba Avezum Alves de
author_role author
author2 Castro-Prado,Marialba Avezum Alves de
author2_role author
dc.contributor.author.fl_str_mv Chiuchetta,Simone Jurema Ruggeri
Castro-Prado,Marialba Avezum Alves de
dc.subject.por.fl_str_mv antineoplastic agents
mitotic crossing-over
secondary malignances
topic antineoplastic agents
mitotic crossing-over
secondary malignances
description Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells.
publishDate 2002
dc.date.none.fl_str_mv 2002-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822002000300014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.33 n.3 2002
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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