Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014 |
Resumo: | Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells. |
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Brazilian Journal of Microbiology |
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Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulansantineoplastic agentsmitotic crossing-oversecondary malignancesDoxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells.Sociedade Brasileira de Microbiologia2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014Brazilian Journal of Microbiology v.33 n.3 2002reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822002000300014info:eu-repo/semantics/openAccessChiuchetta,Simone Jurema RuggeriCastro-Prado,Marialba Avezum Alves deeng2003-06-23T00:00:00Zoai:scielo:S1517-83822002000300014Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2003-06-23T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
title |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
spellingShingle |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans Chiuchetta,Simone Jurema Ruggeri antineoplastic agents mitotic crossing-over secondary malignances |
title_short |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
title_full |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
title_fullStr |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
title_full_unstemmed |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
title_sort |
Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans |
author |
Chiuchetta,Simone Jurema Ruggeri |
author_facet |
Chiuchetta,Simone Jurema Ruggeri Castro-Prado,Marialba Avezum Alves de |
author_role |
author |
author2 |
Castro-Prado,Marialba Avezum Alves de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Chiuchetta,Simone Jurema Ruggeri Castro-Prado,Marialba Avezum Alves de |
dc.subject.por.fl_str_mv |
antineoplastic agents mitotic crossing-over secondary malignances |
topic |
antineoplastic agents mitotic crossing-over secondary malignances |
description |
Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1517-83822002000300014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.33 n.3 2002 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122199310860288 |