Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000300365 |
Resumo: | Abstract INTRODUCTION: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. METHODS: Toxins from the venom of M. surinamensis were analyzed by two-dimensional polyacrylamide gel electrophoresis and their neurotoxic effects in vivo were evaluated. RESULTS AND CONCLUSIONS: Most proteins in the venom had masses < 14kDa, low phospholipase A2 activity, and no proteolytic activity. The toxins inhibited the coagulation cascade. The venom had neurotoxic effects in mice, with a median lethal dose upon intravenous administration of 700 µg/kg. Immunogenic studies revealed abundant cross-reactivity of antielapidic serum with 14kDa toxins and limited cross-reactivity with toxins < 10kDa. These results indicate that antielapidic serum against M. surinamensis venom has weak potency (0.35mg/ml) in mice. |
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Revista da Sociedade Brasileira de Medicina Tropical |
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Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensisMicrurus surinamensisNeurotoxinsPhospholipase A2Biological activitiesAbstract INTRODUCTION: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. METHODS: Toxins from the venom of M. surinamensis were analyzed by two-dimensional polyacrylamide gel electrophoresis and their neurotoxic effects in vivo were evaluated. RESULTS AND CONCLUSIONS: Most proteins in the venom had masses < 14kDa, low phospholipase A2 activity, and no proteolytic activity. The toxins inhibited the coagulation cascade. The venom had neurotoxic effects in mice, with a median lethal dose upon intravenous administration of 700 µg/kg. Immunogenic studies revealed abundant cross-reactivity of antielapidic serum with 14kDa toxins and limited cross-reactivity with toxins < 10kDa. These results indicate that antielapidic serum against M. surinamensis venom has weak potency (0.35mg/ml) in mice.Sociedade Brasileira de Medicina Tropical - SBMT2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000300365Revista da Sociedade Brasileira de Medicina Tropical v.50 n.3 2017reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0408-2016info:eu-repo/semantics/openAccessOliveira,Fabiana da RochaNoronha,Maria das Dores NogueiraLozano,Jorge Luis Lopezeng2017-09-12T00:00:00Zoai:scielo:S0037-86822017000300365Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2017-09-12T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
title |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
spellingShingle |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis Oliveira,Fabiana da Rocha Micrurus surinamensis Neurotoxins Phospholipase A2 Biological activities |
title_short |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
title_full |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
title_fullStr |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
title_full_unstemmed |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
title_sort |
Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
author |
Oliveira,Fabiana da Rocha |
author_facet |
Oliveira,Fabiana da Rocha Noronha,Maria das Dores Nogueira Lozano,Jorge Luis Lopez |
author_role |
author |
author2 |
Noronha,Maria das Dores Nogueira Lozano,Jorge Luis Lopez |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Oliveira,Fabiana da Rocha Noronha,Maria das Dores Nogueira Lozano,Jorge Luis Lopez |
dc.subject.por.fl_str_mv |
Micrurus surinamensis Neurotoxins Phospholipase A2 Biological activities |
topic |
Micrurus surinamensis Neurotoxins Phospholipase A2 Biological activities |
description |
Abstract INTRODUCTION: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. METHODS: Toxins from the venom of M. surinamensis were analyzed by two-dimensional polyacrylamide gel electrophoresis and their neurotoxic effects in vivo were evaluated. RESULTS AND CONCLUSIONS: Most proteins in the venom had masses < 14kDa, low phospholipase A2 activity, and no proteolytic activity. The toxins inhibited the coagulation cascade. The venom had neurotoxic effects in mice, with a median lethal dose upon intravenous administration of 700 µg/kg. Immunogenic studies revealed abundant cross-reactivity of antielapidic serum with 14kDa toxins and limited cross-reactivity with toxins < 10kDa. These results indicate that antielapidic serum against M. surinamensis venom has weak potency (0.35mg/ml) in mice. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000300365 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000300365 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0408-2016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.50 n.3 2017 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122160670834688 |