Overview of polymyxin resistance in Enterobacteriaceae

Detalhes bibliográficos
Autor(a) principal: Silva,Kesia Esther da
Data de Publicação: 2022
Outros Autores: Rossato,Luana, Leite,Andressa Ferraz, Simionatto,Simone
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100250
Resumo: ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
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spelling Overview of polymyxin resistance in EnterobacteriaceaeEnterobacteriaPolymyxin resistanceMolecular mechanismEpidemiologyABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.Sociedade Brasileira de Medicina Tropical - SBMT2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100250Revista da Sociedade Brasileira de Medicina Tropical v.55 2022reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0349-2021info:eu-repo/semantics/openAccessSilva,Kesia Esther daRossato,LuanaLeite,Andressa FerrazSimionatto,Simoneeng2022-02-23T00:00:00Zoai:scielo:S0037-86822022000100250Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2022-02-23T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Overview of polymyxin resistance in Enterobacteriaceae
title Overview of polymyxin resistance in Enterobacteriaceae
spellingShingle Overview of polymyxin resistance in Enterobacteriaceae
Silva,Kesia Esther da
Enterobacteria
Polymyxin resistance
Molecular mechanism
Epidemiology
title_short Overview of polymyxin resistance in Enterobacteriaceae
title_full Overview of polymyxin resistance in Enterobacteriaceae
title_fullStr Overview of polymyxin resistance in Enterobacteriaceae
title_full_unstemmed Overview of polymyxin resistance in Enterobacteriaceae
title_sort Overview of polymyxin resistance in Enterobacteriaceae
author Silva,Kesia Esther da
author_facet Silva,Kesia Esther da
Rossato,Luana
Leite,Andressa Ferraz
Simionatto,Simone
author_role author
author2 Rossato,Luana
Leite,Andressa Ferraz
Simionatto,Simone
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Kesia Esther da
Rossato,Luana
Leite,Andressa Ferraz
Simionatto,Simone
dc.subject.por.fl_str_mv Enterobacteria
Polymyxin resistance
Molecular mechanism
Epidemiology
topic Enterobacteria
Polymyxin resistance
Molecular mechanism
Epidemiology
description ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100250
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100250
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0349-2021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.55 2022
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
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instacron_str SBMT
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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