Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children

Detalhes bibliográficos
Autor(a) principal: Pamplona,Mônica Custódia do Couto Abreu
Data de Publicação: 2019
Outros Autores: Chaves,Emanuele Cordeiro, Carvalho,Alôma Cecília, Pamplona,Rúdrissa do Couto Abreu, Vallinoto,Antonio Carlos Rosário, Queiroz,Maria Alice Freitas, Lima,Sandra Souza, Ishak,Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301
Resumo: Abstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role.
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spelling Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in childrenHIV-1Vertical transmissionNeurological damageAbstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role.Sociedade Brasileira de Medicina Tropical - SBMT2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301Revista da Sociedade Brasileira de Medicina Tropical v.52 2019reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0263-2018info:eu-repo/semantics/openAccessPamplona,Mônica Custódia do Couto AbreuChaves,Emanuele CordeiroCarvalho,Alôma CecíliaPamplona,Rúdrissa do Couto AbreuVallinoto,Antonio Carlos RosárioQueiroz,Maria Alice FreitasLima,Sandra SouzaIshak,Ricardoeng2019-01-10T00:00:00Zoai:scielo:S0037-86822019000100301Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2019-01-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
title Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
spellingShingle Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
Pamplona,Mônica Custódia do Couto Abreu
HIV-1
Vertical transmission
Neurological damage
title_short Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
title_full Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
title_fullStr Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
title_full_unstemmed Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
title_sort Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
author Pamplona,Mônica Custódia do Couto Abreu
author_facet Pamplona,Mônica Custódia do Couto Abreu
Chaves,Emanuele Cordeiro
Carvalho,Alôma Cecília
Pamplona,Rúdrissa do Couto Abreu
Vallinoto,Antonio Carlos Rosário
Queiroz,Maria Alice Freitas
Lima,Sandra Souza
Ishak,Ricardo
author_role author
author2 Chaves,Emanuele Cordeiro
Carvalho,Alôma Cecília
Pamplona,Rúdrissa do Couto Abreu
Vallinoto,Antonio Carlos Rosário
Queiroz,Maria Alice Freitas
Lima,Sandra Souza
Ishak,Ricardo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pamplona,Mônica Custódia do Couto Abreu
Chaves,Emanuele Cordeiro
Carvalho,Alôma Cecília
Pamplona,Rúdrissa do Couto Abreu
Vallinoto,Antonio Carlos Rosário
Queiroz,Maria Alice Freitas
Lima,Sandra Souza
Ishak,Ricardo
dc.subject.por.fl_str_mv HIV-1
Vertical transmission
Neurological damage
topic HIV-1
Vertical transmission
Neurological damage
description Abstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/0037-8682-0263-2018
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.52 2019
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
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instacron_str SBMT
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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