Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301 |
Resumo: | Abstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role. |
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Revista da Sociedade Brasileira de Medicina Tropical |
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Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in childrenHIV-1Vertical transmissionNeurological damageAbstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role.Sociedade Brasileira de Medicina Tropical - SBMT2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301Revista da Sociedade Brasileira de Medicina Tropical v.52 2019reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0263-2018info:eu-repo/semantics/openAccessPamplona,Mônica Custódia do Couto AbreuChaves,Emanuele CordeiroCarvalho,Alôma CecíliaPamplona,Rúdrissa do Couto AbreuVallinoto,Antonio Carlos RosárioQueiroz,Maria Alice FreitasLima,Sandra SouzaIshak,Ricardoeng2019-01-10T00:00:00Zoai:scielo:S0037-86822019000100301Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2019-01-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
title |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
spellingShingle |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children Pamplona,Mônica Custódia do Couto Abreu HIV-1 Vertical transmission Neurological damage |
title_short |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
title_full |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
title_fullStr |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
title_full_unstemmed |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
title_sort |
Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children |
author |
Pamplona,Mônica Custódia do Couto Abreu |
author_facet |
Pamplona,Mônica Custódia do Couto Abreu Chaves,Emanuele Cordeiro Carvalho,Alôma Cecília Pamplona,Rúdrissa do Couto Abreu Vallinoto,Antonio Carlos Rosário Queiroz,Maria Alice Freitas Lima,Sandra Souza Ishak,Ricardo |
author_role |
author |
author2 |
Chaves,Emanuele Cordeiro Carvalho,Alôma Cecília Pamplona,Rúdrissa do Couto Abreu Vallinoto,Antonio Carlos Rosário Queiroz,Maria Alice Freitas Lima,Sandra Souza Ishak,Ricardo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Pamplona,Mônica Custódia do Couto Abreu Chaves,Emanuele Cordeiro Carvalho,Alôma Cecília Pamplona,Rúdrissa do Couto Abreu Vallinoto,Antonio Carlos Rosário Queiroz,Maria Alice Freitas Lima,Sandra Souza Ishak,Ricardo |
dc.subject.por.fl_str_mv |
HIV-1 Vertical transmission Neurological damage |
topic |
HIV-1 Vertical transmission Neurological damage |
description |
Abstract INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services. METHODS: Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test. RESULTS: Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes. CONCLUSIONS: Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0263-2018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.52 2019 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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