Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/879 |
Resumo: | ABSTRACT. Ramos M.I.M., Leal P.D.S., Barbosa L.L.deO. & Lopes C.W.G. Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil. [Hiperadrenocorticismo em cães atendidos em serviço de saúde animal na cidade do Rio de Janeiro, Brasil.] Revista Brasileira de Medicina Veterinária, 38(Supl. 3):42-48, 2016. Programa de Pós-Graduação em Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Campus Seropédica, RJ, 23.890-000, Brasil. E-mail: mariaisabelmrm@gmail.com The hyperadrenocorticism (HAC), or Cushing’s syndrome (CS) is an endocrine disease diagnosed in dogs associated with excessive endogenous glucocorticoid by pituitary or adrenal neoplasm, by iatrogenic (IHAC) induced by excessive administration of oral glucocorticoids, parenteral or topical. These changes are identified by physical examination, no specific laboratory tests (blood counts, urinalysis, lipid profile, alkaline phosphatase dosage and liver function profiles) and confirmed by a specific test. Clinical and laboratory manifestations vary among animals due to individual differences in cortisol sensitivity, with the absence or presence of clinical and laboratory signs. Due to the importance of this disease in the dog clinic for producing systemic effects, this work had the objective of studying in 21 dogs where they were tested by stimulation of adrenocorticotropic hormone (ACTH) for HAC. Animals, which had some consistent factor for HAC as recurrent urinary tract infections, cholesterol or triglycerides and after fasting for more than 12 hours or alkaline phosphatase levels above the normal range without presenting hepatic and bone disease, they underwent adrenocorticotropic hormone stimulation test (ACTH-adrenocorticotropic hormone) synthetic dose 0.25 mL/ dog. Dogs with cortisol results after stimulation by ACTH, above 20 mcg/dL, had a confirmed diagnosis of hyperadrenocorticism. Of 21 dogs studied, 10 were diagnosed for HAC. Of these, eight dogs were positive for some species of blood parasites where six with monoinfection by Anaplasma platys and only one dog had multiple infection by A. platys and Mycoplasma canis. The hematological findings showed three dogs with anemia, four with thrombocytopenia, two with thrombocytosis, two with leukocytosis, six with eosinopenia, seven with neutrophilic, six with lymphopenia, five with monocytopenia and seven dogs with neutrophils on rods and left shunt, and six with hyperproteinaemia. Just a positive HAC dog did not have any concomitant infection. The results of biochemical evaluation showed eight animals with elevated alkaline phosphatase. Finally, when diagnosing hyperdrenocorticism in dogs, no correlation was observed with laboratory findings, other than alkaline phosphatase above 984 U/L and positive dogs for HAC. |
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Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, BrazilHiperadrenocorticismo em cães atendidos em serviço de saúde animal na cidade do Rio de Janeiro, BrasilSíndrome de Cushingcãescortisoladrenalfosfatase alcalinaCushing’s syndromedogscortisoladrenalphosphatase alkalineABSTRACT. Ramos M.I.M., Leal P.D.S., Barbosa L.L.deO. & Lopes C.W.G. Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil. [Hiperadrenocorticismo em cães atendidos em serviço de saúde animal na cidade do Rio de Janeiro, Brasil.] Revista Brasileira de Medicina Veterinária, 38(Supl. 3):42-48, 2016. Programa de Pós-Graduação em Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Campus Seropédica, RJ, 23.890-000, Brasil. E-mail: mariaisabelmrm@gmail.com The hyperadrenocorticism (HAC), or Cushing’s syndrome (CS) is an endocrine disease diagnosed in dogs associated with excessive endogenous glucocorticoid by pituitary or adrenal neoplasm, by iatrogenic (IHAC) induced by excessive administration of oral glucocorticoids, parenteral or topical. These changes are identified by physical examination, no specific laboratory tests (blood counts, urinalysis, lipid profile, alkaline phosphatase dosage and liver function profiles) and confirmed by a specific test. Clinical and laboratory manifestations vary among animals due to individual differences in cortisol sensitivity, with the absence or presence of clinical and laboratory signs. Due to the importance of this disease in the dog clinic for producing systemic effects, this work had the objective of studying in 21 dogs where they were tested by stimulation of adrenocorticotropic hormone (ACTH) for HAC. Animals, which had some consistent factor for HAC as recurrent urinary tract infections, cholesterol or triglycerides and after fasting for more than 12 hours or alkaline phosphatase levels above the normal range without presenting hepatic and bone disease, they underwent adrenocorticotropic hormone stimulation test (ACTH-adrenocorticotropic hormone) synthetic dose 0.25 mL/ dog. Dogs with cortisol results after stimulation by ACTH, above 20 mcg/dL, had a confirmed diagnosis of hyperadrenocorticism. Of 21 dogs studied, 10 were diagnosed for HAC. Of these, eight dogs were positive for some species of blood parasites where six with monoinfection by Anaplasma platys and only one dog had multiple infection by A. platys and Mycoplasma canis. The hematological findings showed three dogs with anemia, four with thrombocytopenia, two with thrombocytosis, two with leukocytosis, six with eosinopenia, seven with neutrophilic, six with lymphopenia, five with monocytopenia and seven dogs with neutrophils on rods and left shunt, and six with hyperproteinaemia. Just a positive HAC dog did not have any concomitant infection. The results of biochemical evaluation showed eight animals with elevated alkaline phosphatase. Finally, when diagnosing hyperdrenocorticism in dogs, no correlation was observed with laboratory findings, other than alkaline phosphatase above 984 U/L and positive dogs for HAC.O hiperadrenocorticismo (HAC), ou síndrome de Cushing (CS), é uma doença endócrina diagnosticada em cães associados à glicocorticoides endógenos excessivos por neoplasia pituitária ou adrenal, por iatrogenia (IHAC) induzida pela administração excessiva de glicocorticoides por via oral, parenteral ou tópica. Estas alterações são identificadas por exame físico, sem testes laboratoriais específicos como hemograma, análise de urina, perfil lipídico, dosagem de fosfatase alcalina e perfis de função hepática e confirmados por um teste específico. As manifestações clínicas e laboratoriais variam entre os animais devido às diferenças individuais na sensibilidade ao cortisol, com ausência ou presença de sinais clínicos e laboratoriais. Dada à importância desta doença na clínica de cães por produzir efeitos sistêmicos, este trabalho teve como objetivo estudar em 21 cães que foram testados com estimulação por hormônio adrenocorticotrópico (ACTH) para HAC. Cães que tinham algum fator consistente para HAC, como infecções urinárias recorrentes, colesterol ou triglicérides. Após jejum por mais de 12 horas ou níveis de fosfatase alcalina acima do intervalo normal sem apresentar doença hepática e óssea, foram submetidos a uma dose sintética de hormônio adrenocorticotrópico (ACTH-adrenocorticotropic hormone) 0,25 mL/cão. Cães com resultados de cortisol após estimulação com ACTH, acima de 20 mcg/dL, tiveram diagnóstico confirmado de hiperadrenocorticismo. Dos 21 cães estudados, 10 foram diagnosticados para HAC, destes, oito cães foram positivos para algumas espécies de parasitas sanguíneos onde seis com monoinfection por Anaplasma platys e apenas um cão teve infecção múltipla por A. platys e Mycoplasma canis. Os achados hematológicos mostraram três cães com anemia, quatro com trombocitopenia, dois com trombocitose, dois com leucocitose, seis com eosinopenia, sete com neutrofílico, seis com linfopenia, cinco com monocitopenia e sete cães com neutrófilos em hastes e shunt esquerdo e seis com Hiperproteinemia. Apenas um cão HAC positivo não teve qualquer infecção concomitante. Os resultados da avaliação bioquímica mostraram oito com fosfatase alcalina elevada. Nenhuma das alterações hematológicas observadas tem correlação positiva, embora somente os cães com fosfatase alcalina acima de 984 U/L tenham sido positivos para HAC. Finalmente, ao diagnosticar o hiperdrenocorticismo em cães, não foi observada correlação com achados laboratoriais, exceto a fosfatase alcalina acima de 984 U/L e cães positivos para HAC.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/879Brazilian Journal of Veterinary Medicine; Vol. 38 No. Supl. 3 (2016); 42-48Revista Brasileira de Medicina Veterinária; v. 38 n. Supl. 3 (2016); 42-482527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/879/723Ramos, Maria Isabel MenezesLeal, Paulo Daniel Sant’AnnaBarbosa, Larissa Licurci de OliveiraLopes, Carlos Wilson Gomesinfo:eu-repo/semantics/openAccess2020-12-23T17:34:25Zoai:ojs.rbmv.org:article/879Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:34:25Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil Hiperadrenocorticismo em cães atendidos em serviço de saúde animal na cidade do Rio de Janeiro, Brasil |
title |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
spellingShingle |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil Ramos, Maria Isabel Menezes Síndrome de Cushing cães cortisol adrenal fosfatase alcalina Cushing’s syndrome dogs cortisol adrenal phosphatase alkaline |
title_short |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
title_full |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
title_fullStr |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
title_full_unstemmed |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
title_sort |
Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil |
author |
Ramos, Maria Isabel Menezes |
author_facet |
Ramos, Maria Isabel Menezes Leal, Paulo Daniel Sant’Anna Barbosa, Larissa Licurci de Oliveira Lopes, Carlos Wilson Gomes |
author_role |
author |
author2 |
Leal, Paulo Daniel Sant’Anna Barbosa, Larissa Licurci de Oliveira Lopes, Carlos Wilson Gomes |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ramos, Maria Isabel Menezes Leal, Paulo Daniel Sant’Anna Barbosa, Larissa Licurci de Oliveira Lopes, Carlos Wilson Gomes |
dc.subject.por.fl_str_mv |
Síndrome de Cushing cães cortisol adrenal fosfatase alcalina Cushing’s syndrome dogs cortisol adrenal phosphatase alkaline |
topic |
Síndrome de Cushing cães cortisol adrenal fosfatase alcalina Cushing’s syndrome dogs cortisol adrenal phosphatase alkaline |
description |
ABSTRACT. Ramos M.I.M., Leal P.D.S., Barbosa L.L.deO. & Lopes C.W.G. Hyperadrenocorticism in dogs attended at the Animal Health Service in the City of Rio de Janeiro, Brazil. [Hiperadrenocorticismo em cães atendidos em serviço de saúde animal na cidade do Rio de Janeiro, Brasil.] Revista Brasileira de Medicina Veterinária, 38(Supl. 3):42-48, 2016. Programa de Pós-Graduação em Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Campus Seropédica, RJ, 23.890-000, Brasil. E-mail: mariaisabelmrm@gmail.com The hyperadrenocorticism (HAC), or Cushing’s syndrome (CS) is an endocrine disease diagnosed in dogs associated with excessive endogenous glucocorticoid by pituitary or adrenal neoplasm, by iatrogenic (IHAC) induced by excessive administration of oral glucocorticoids, parenteral or topical. These changes are identified by physical examination, no specific laboratory tests (blood counts, urinalysis, lipid profile, alkaline phosphatase dosage and liver function profiles) and confirmed by a specific test. Clinical and laboratory manifestations vary among animals due to individual differences in cortisol sensitivity, with the absence or presence of clinical and laboratory signs. Due to the importance of this disease in the dog clinic for producing systemic effects, this work had the objective of studying in 21 dogs where they were tested by stimulation of adrenocorticotropic hormone (ACTH) for HAC. Animals, which had some consistent factor for HAC as recurrent urinary tract infections, cholesterol or triglycerides and after fasting for more than 12 hours or alkaline phosphatase levels above the normal range without presenting hepatic and bone disease, they underwent adrenocorticotropic hormone stimulation test (ACTH-adrenocorticotropic hormone) synthetic dose 0.25 mL/ dog. Dogs with cortisol results after stimulation by ACTH, above 20 mcg/dL, had a confirmed diagnosis of hyperadrenocorticism. Of 21 dogs studied, 10 were diagnosed for HAC. Of these, eight dogs were positive for some species of blood parasites where six with monoinfection by Anaplasma platys and only one dog had multiple infection by A. platys and Mycoplasma canis. The hematological findings showed three dogs with anemia, four with thrombocytopenia, two with thrombocytosis, two with leukocytosis, six with eosinopenia, seven with neutrophilic, six with lymphopenia, five with monocytopenia and seven dogs with neutrophils on rods and left shunt, and six with hyperproteinaemia. Just a positive HAC dog did not have any concomitant infection. The results of biochemical evaluation showed eight animals with elevated alkaline phosphatase. Finally, when diagnosing hyperdrenocorticism in dogs, no correlation was observed with laboratory findings, other than alkaline phosphatase above 984 U/L and positive dogs for HAC. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/879 |
url |
https://rbmv.org/BJVM/article/view/879 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/879/723 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 38 No. Supl. 3 (2016); 42-48 Revista Brasileira de Medicina Veterinária; v. 38 n. Supl. 3 (2016); 42-48 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110080061440 |