The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism

Detalhes bibliográficos
Autor(a) principal: Reda,Seme Youssef
Data de Publicação: 2013
Outros Autores: Martins,Marina Lobato
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600004
Resumo: This study aimed at making the differential diagnosis of joint disease in a case of genetic chimerism in a female multiparous donor from the Regional Blood Bank of Guarapuava-PR (Hemocentro Regional de Guarapuava-PR), who had had three pregnancies of male fetuses. The patient showed joint pain prior to the last donation. It was possible to identify fetal cells remaining in circulation 20 years after her last pregnancy. Laboratory tests for acute phase proteins revealed possible termination of immune tolerance to circulating fetal cells. Thus, a hypothesis of graft-versus-host disease was formulated to explain the joint disease manifested by the donor.
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spelling The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerismhemotherapy servicechimerapregnanciestriagedonor selectionThis study aimed at making the differential diagnosis of joint disease in a case of genetic chimerism in a female multiparous donor from the Regional Blood Bank of Guarapuava-PR (Hemocentro Regional de Guarapuava-PR), who had had three pregnancies of male fetuses. The patient showed joint pain prior to the last donation. It was possible to identify fetal cells remaining in circulation 20 years after her last pregnancy. Laboratory tests for acute phase proteins revealed possible termination of immune tolerance to circulating fetal cells. Thus, a hypothesis of graft-versus-host disease was formulated to explain the joint disease manifested by the donor.Sociedade Brasileira de Patologia Clínica2013-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600004Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.6 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000600004info:eu-repo/semantics/openAccessReda,Seme YoussefMartins,Marina Lobatoeng2014-01-07T00:00:00Zoai:scielo:S1676-24442013000600004Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2014-01-07T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
title The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
spellingShingle The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
Reda,Seme Youssef
hemotherapy service
chimera
pregnancies
triage
donor selection
title_short The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
title_full The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
title_fullStr The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
title_full_unstemmed The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
title_sort The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism
author Reda,Seme Youssef
author_facet Reda,Seme Youssef
Martins,Marina Lobato
author_role author
author2 Martins,Marina Lobato
author2_role author
dc.contributor.author.fl_str_mv Reda,Seme Youssef
Martins,Marina Lobato
dc.subject.por.fl_str_mv hemotherapy service
chimera
pregnancies
triage
donor selection
topic hemotherapy service
chimera
pregnancies
triage
donor selection
description This study aimed at making the differential diagnosis of joint disease in a case of genetic chimerism in a female multiparous donor from the Regional Blood Bank of Guarapuava-PR (Hemocentro Regional de Guarapuava-PR), who had had three pregnancies of male fetuses. The patient showed joint pain prior to the last donation. It was possible to identify fetal cells remaining in circulation 20 years after her last pregnancy. Laboratory tests for acute phase proteins revealed possible termination of immune tolerance to circulating fetal cells. Thus, a hypothesis of graft-versus-host disease was formulated to explain the joint disease manifested by the donor.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442013000600004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.6 2013
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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