Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide,
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000300302 |
Resumo: | Abstract Objective: To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. Methods: Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160 pmol/kg for four consecutive days. To evaluate the results, parental impressions the Childhood Autism Rating Scale (CARS) and the Clinical Global Impression (CGI) Scale. Each child underwent a new peptide cycle after two weeks. The children were followed for four weeks after the end of the infusions. Results: The gastrin-releasing peptide was well tolerated and no child had adverse effects. Two children had improved social interaction, with a slight improvement in joint attention and the interaction initiatives. Two showed reduction of stereotypes and improvement in verbal language. One child lost his compulsion to bathe, an effect that lasted two weeks after each infusion cycle. Average reduction in CARS score was 2.8 points. CGI was "minimally better" in two children and "much better" in one. Conclusions: This study suggests that the gastrin-releasing peptide is safe and may be effective in improving key symptoms of autism spectrum disorder, but its results should be interpreted with caution. Controlled clinical trials-randomized, double-blinded, and with more children-are needed to better evaluate the possible therapeutic effects of gastrin-releasing peptide in autism. |
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Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide,Gastrin-releasing peptide receptorNeuropeptidesAutismAutism spectrum disorderAbstract Objective: To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. Methods: Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160 pmol/kg for four consecutive days. To evaluate the results, parental impressions the Childhood Autism Rating Scale (CARS) and the Clinical Global Impression (CGI) Scale. Each child underwent a new peptide cycle after two weeks. The children were followed for four weeks after the end of the infusions. Results: The gastrin-releasing peptide was well tolerated and no child had adverse effects. Two children had improved social interaction, with a slight improvement in joint attention and the interaction initiatives. Two showed reduction of stereotypes and improvement in verbal language. One child lost his compulsion to bathe, an effect that lasted two weeks after each infusion cycle. Average reduction in CARS score was 2.8 points. CGI was "minimally better" in two children and "much better" in one. Conclusions: This study suggests that the gastrin-releasing peptide is safe and may be effective in improving key symptoms of autism spectrum disorder, but its results should be interpreted with caution. Controlled clinical trials-randomized, double-blinded, and with more children-are needed to better evaluate the possible therapeutic effects of gastrin-releasing peptide in autism.Sociedade Brasileira de Pediatria2016-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000300302Jornal de Pediatria v.92 n.3 2016reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2015.08.012info:eu-repo/semantics/openAccessBecker,Michele MichelinBosa,CleoniceOliveira-Freitas,Vera LorentzGoldim,José RobertoOhlweiler,LygiaRoesler,RafaelSchwartsmann,GilbertoRiesgo,Rudimar dos Santoseng2016-06-21T00:00:00Zoai:scielo:S0021-75572016000300302Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2016-06-21T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
title |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
spellingShingle |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, Becker,Michele Michelin Gastrin-releasing peptide receptor Neuropeptides Autism Autism spectrum disorder |
title_short |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
title_full |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
title_fullStr |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
title_full_unstemmed |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
title_sort |
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide, |
author |
Becker,Michele Michelin |
author_facet |
Becker,Michele Michelin Bosa,Cleonice Oliveira-Freitas,Vera Lorentz Goldim,José Roberto Ohlweiler,Lygia Roesler,Rafael Schwartsmann,Gilberto Riesgo,Rudimar dos Santos |
author_role |
author |
author2 |
Bosa,Cleonice Oliveira-Freitas,Vera Lorentz Goldim,José Roberto Ohlweiler,Lygia Roesler,Rafael Schwartsmann,Gilberto Riesgo,Rudimar dos Santos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Becker,Michele Michelin Bosa,Cleonice Oliveira-Freitas,Vera Lorentz Goldim,José Roberto Ohlweiler,Lygia Roesler,Rafael Schwartsmann,Gilberto Riesgo,Rudimar dos Santos |
dc.subject.por.fl_str_mv |
Gastrin-releasing peptide receptor Neuropeptides Autism Autism spectrum disorder |
topic |
Gastrin-releasing peptide receptor Neuropeptides Autism Autism spectrum disorder |
description |
Abstract Objective: To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. Methods: Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160 pmol/kg for four consecutive days. To evaluate the results, parental impressions the Childhood Autism Rating Scale (CARS) and the Clinical Global Impression (CGI) Scale. Each child underwent a new peptide cycle after two weeks. The children were followed for four weeks after the end of the infusions. Results: The gastrin-releasing peptide was well tolerated and no child had adverse effects. Two children had improved social interaction, with a slight improvement in joint attention and the interaction initiatives. Two showed reduction of stereotypes and improvement in verbal language. One child lost his compulsion to bathe, an effect that lasted two weeks after each infusion cycle. Average reduction in CARS score was 2.8 points. CGI was "minimally better" in two children and "much better" in one. Conclusions: This study suggests that the gastrin-releasing peptide is safe and may be effective in improving key symptoms of autism spectrum disorder, but its results should be interpreted with caution. Controlled clinical trials-randomized, double-blinded, and with more children-are needed to better evaluate the possible therapeutic effects of gastrin-releasing peptide in autism. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000300302 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000300302 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2015.08.012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.92 n.3 2016 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122320538828800 |