Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000600624 |
Resumo: | OBJECTIVE: To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB). METHODS: This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA). RESULTS: BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B. CONCLUSIONS: BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3. |
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Jornal de Pediatria (Online) |
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Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents AdolescentsBone mineral densityBone mineralizationBone remodelingBone reabsorptionOsteocalcinOsteoporosisGrowthBone health OBJECTIVE: To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB). METHODS: This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA). RESULTS: BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B. CONCLUSIONS: BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3. Sociedade Brasileira de Pediatria2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000600624Jornal de Pediatria v.90 n.6 2014reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2014.04.008info:eu-repo/semantics/openAccessFortes,Cristina Maria TeixeiraGoldberg,Tamara Beres LedererKurokawa,Cilmery SuemiSilva,Carla CristianiMoretto,Maria ReginaBiason,Talita PoliTeixeira,Altamir SantosNunes,Hélio Rubens de Carvalhoeng2015-08-25T00:00:00Zoai:scielo:S0021-75572014000600624Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2015-08-25T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
spellingShingle |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents Fortes,Cristina Maria Teixeira Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health |
title_short |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_full |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_fullStr |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_full_unstemmed |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_sort |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
author |
Fortes,Cristina Maria Teixeira |
author_facet |
Fortes,Cristina Maria Teixeira Goldberg,Tamara Beres Lederer Kurokawa,Cilmery Suemi Silva,Carla Cristiani Moretto,Maria Regina Biason,Talita Poli Teixeira,Altamir Santos Nunes,Hélio Rubens de Carvalho |
author_role |
author |
author2 |
Goldberg,Tamara Beres Lederer Kurokawa,Cilmery Suemi Silva,Carla Cristiani Moretto,Maria Regina Biason,Talita Poli Teixeira,Altamir Santos Nunes,Hélio Rubens de Carvalho |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Fortes,Cristina Maria Teixeira Goldberg,Tamara Beres Lederer Kurokawa,Cilmery Suemi Silva,Carla Cristiani Moretto,Maria Regina Biason,Talita Poli Teixeira,Altamir Santos Nunes,Hélio Rubens de Carvalho |
dc.subject.por.fl_str_mv |
Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health |
topic |
Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health |
description |
OBJECTIVE: To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB). METHODS: This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA). RESULTS: BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B. CONCLUSIONS: BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000600624 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000600624 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2014.04.008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.90 n.6 2014 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122320037609472 |