Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease

Detalhes bibliográficos
Autor(a) principal: Khan,Shahida A.
Data de Publicação: 2022
Outros Autores: Damanhouri,Ghazi A., Ahmed,Tahir J., Halawani,Saeed H., Ali,Ashraf, Makki,Ahmad, Khan,Sarah A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513
Resumo: Abstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease.
id SBPE-1_e35bff1e7013b835c6d3933c275f378c
oai_identifier_str oai:scielo:S0021-75572022000500513
network_acronym_str SBPE-1
network_name_str Jornal de Pediatria (Online)
repository_id_str
spelling Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell diseaseSickle cell diseaseOxidative stressInflammationOmega-3 fatty acidsAbstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease.Sociedade Brasileira de Pediatria2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513Jornal de Pediatria v.98 n.5 2022reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2022.01.001info:eu-repo/semantics/openAccessKhan,Shahida A.Damanhouri,Ghazi A.Ahmed,Tahir J.Halawani,Saeed H.Ali,AshrafMakki,AhmadKhan,Sarah A.eng2022-10-19T00:00:00Zoai:scielo:S0021-75572022000500513Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2022-10-19T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
title Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
spellingShingle Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
Khan,Shahida A.
Sickle cell disease
Oxidative stress
Inflammation
Omega-3 fatty acids
title_short Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
title_full Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
title_fullStr Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
title_full_unstemmed Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
title_sort Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
author Khan,Shahida A.
author_facet Khan,Shahida A.
Damanhouri,Ghazi A.
Ahmed,Tahir J.
Halawani,Saeed H.
Ali,Ashraf
Makki,Ahmad
Khan,Sarah A.
author_role author
author2 Damanhouri,Ghazi A.
Ahmed,Tahir J.
Halawani,Saeed H.
Ali,Ashraf
Makki,Ahmad
Khan,Sarah A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Khan,Shahida A.
Damanhouri,Ghazi A.
Ahmed,Tahir J.
Halawani,Saeed H.
Ali,Ashraf
Makki,Ahmad
Khan,Sarah A.
dc.subject.por.fl_str_mv Sickle cell disease
Oxidative stress
Inflammation
Omega-3 fatty acids
topic Sickle cell disease
Oxidative stress
Inflammation
Omega-3 fatty acids
description Abstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2022.01.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.98 n.5 2022
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
instname_str Sociedade Brasileira de Pediatria (SBP)
instacron_str SBPE
institution SBPE
reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
repository.mail.fl_str_mv ||jped@jped.com.br
_version_ 1752122323354255360