Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513 |
Resumo: | Abstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease. |
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Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell diseaseSickle cell diseaseOxidative stressInflammationOmega-3 fatty acidsAbstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease.Sociedade Brasileira de Pediatria2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513Jornal de Pediatria v.98 n.5 2022reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2022.01.001info:eu-repo/semantics/openAccessKhan,Shahida A.Damanhouri,Ghazi A.Ahmed,Tahir J.Halawani,Saeed H.Ali,AshrafMakki,AhmadKhan,Sarah A.eng2022-10-19T00:00:00Zoai:scielo:S0021-75572022000500513Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2022-10-19T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
title |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
spellingShingle |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease Khan,Shahida A. Sickle cell disease Oxidative stress Inflammation Omega-3 fatty acids |
title_short |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
title_full |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
title_fullStr |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
title_full_unstemmed |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
title_sort |
Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease |
author |
Khan,Shahida A. |
author_facet |
Khan,Shahida A. Damanhouri,Ghazi A. Ahmed,Tahir J. Halawani,Saeed H. Ali,Ashraf Makki,Ahmad Khan,Sarah A. |
author_role |
author |
author2 |
Damanhouri,Ghazi A. Ahmed,Tahir J. Halawani,Saeed H. Ali,Ashraf Makki,Ahmad Khan,Sarah A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Khan,Shahida A. Damanhouri,Ghazi A. Ahmed,Tahir J. Halawani,Saeed H. Ali,Ashraf Makki,Ahmad Khan,Sarah A. |
dc.subject.por.fl_str_mv |
Sickle cell disease Oxidative stress Inflammation Omega-3 fatty acids |
topic |
Sickle cell disease Oxidative stress Inflammation Omega-3 fatty acids |
description |
Abstract Objective Sickle cell disease is characterized by clinical complications resulting in vaso-occlusive crisis with prominent attributes of oxidative stress, inflammation, and pain. Inflammation is an integral part of this disease which further exacerbates the pain during a crisis. Omega-3 fatty acids are known to possess anti-inflammatory and anti-aggregatory properties and assist in diminishing the slow physiological inactivation. Methods A pilot nutritional interventional study was conducted wherein forty-three children with sickle cell disease aged 5-16 years were supplemented with omega-3 fatty acids for a period of six months. Analysis of oxidative stress, as well as inflammatory parameters, was done pre and post-supplementation. Results Increased free oxygen radical transference values depicting free radical generation is enhanced in these patients along with a reduced antioxidant defense, as seen by decreased free oxygen radical defense values. Supplementation with omega-3 fatty acids for a period of six months significantly reduced the inflammatory marker homocysteine in all patients, whereas high sensitive C reactive protein was significantly reduced only in females of the age group 11-16years. Simultaneously a significant reduction in oxidative stress parameters with a concomitant increase of antioxidant defense was observed in all patients. Conclusion The authors’ findings suggest the regulatory effects of omega-3 fatty acids as cellular activators in alleviating the complications due to sickle cell disease. Omega-3 fatty acids hold promise as future therapeutic candidates in patients with sickle cell disease. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000500513 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2022.01.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.98 n.5 2022 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122323354255360 |