Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws

Detalhes bibliográficos
Autor(a) principal: MOTTA,Ana Carolina Fragoso
Data de Publicação: 2015
Outros Autores: MACEDO,Leandro Dorigan de, SANTOS,Gisele Guimarães, GUERREIRO,Carlos Tostes, FERRARI,Tatiane, OLIVEIRA,Thais Feitosa Leitão de, SANTOS,Paulo Sérgio da Silva, OLIVEIRA-SANTOS,Christiano de, RICZ,Hilton Marcos Alves, XAVIER,Samuel Porfírio, IANNETTA,Odilon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301
Resumo: Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.
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spelling Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jawsBisphosphonate-Associated Osteonecrosis of the JawDental CareUltrasonographyBone DensityPatients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301Brazilian Oral Research v.29 n.1 2015reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107BOR-2015.vol29.0106info:eu-repo/semantics/openAccessMOTTA,Ana Carolina FragosoMACEDO,Leandro Dorigan deSANTOS,Gisele GuimarãesGUERREIRO,Carlos TostesFERRARI,TatianeOLIVEIRA,Thais Feitosa Leitão deSANTOS,Paulo Sérgio da SilvaOLIVEIRA-SANTOS,Christiano deRICZ,Hilton Marcos AlvesXAVIER,Samuel PorfírioIANNETTA,Odiloneng2018-08-17T00:00:00Zoai:scielo:S1806-83242015000100301Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-08-17T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
spellingShingle Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
MOTTA,Ana Carolina Fragoso
Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
title_short Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_full Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_fullStr Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_full_unstemmed Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_sort Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
author MOTTA,Ana Carolina Fragoso
author_facet MOTTA,Ana Carolina Fragoso
MACEDO,Leandro Dorigan de
SANTOS,Gisele Guimarães
GUERREIRO,Carlos Tostes
FERRARI,Tatiane
OLIVEIRA,Thais Feitosa Leitão de
SANTOS,Paulo Sérgio da Silva
OLIVEIRA-SANTOS,Christiano de
RICZ,Hilton Marcos Alves
XAVIER,Samuel Porfírio
IANNETTA,Odilon
author_role author
author2 MACEDO,Leandro Dorigan de
SANTOS,Gisele Guimarães
GUERREIRO,Carlos Tostes
FERRARI,Tatiane
OLIVEIRA,Thais Feitosa Leitão de
SANTOS,Paulo Sérgio da Silva
OLIVEIRA-SANTOS,Christiano de
RICZ,Hilton Marcos Alves
XAVIER,Samuel Porfírio
IANNETTA,Odilon
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv MOTTA,Ana Carolina Fragoso
MACEDO,Leandro Dorigan de
SANTOS,Gisele Guimarães
GUERREIRO,Carlos Tostes
FERRARI,Tatiane
OLIVEIRA,Thais Feitosa Leitão de
SANTOS,Paulo Sérgio da Silva
OLIVEIRA-SANTOS,Christiano de
RICZ,Hilton Marcos Alves
XAVIER,Samuel Porfírio
IANNETTA,Odilon
dc.subject.por.fl_str_mv Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
topic Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
description Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1807-3107BOR-2015.vol29.0106
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.29 n.1 2015
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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