Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301 |
Resumo: | Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ. |
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Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jawsBisphosphonate-Associated Osteonecrosis of the JawDental CareUltrasonographyBone DensityPatients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301Brazilian Oral Research v.29 n.1 2015reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107BOR-2015.vol29.0106info:eu-repo/semantics/openAccessMOTTA,Ana Carolina FragosoMACEDO,Leandro Dorigan deSANTOS,Gisele GuimarãesGUERREIRO,Carlos TostesFERRARI,TatianeOLIVEIRA,Thais Feitosa Leitão deSANTOS,Paulo Sérgio da SilvaOLIVEIRA-SANTOS,Christiano deRICZ,Hilton Marcos AlvesXAVIER,Samuel PorfírioIANNETTA,Odiloneng2018-08-17T00:00:00Zoai:scielo:S1806-83242015000100301Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-08-17T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
spellingShingle |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws MOTTA,Ana Carolina Fragoso Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
title_short |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_full |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_fullStr |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_full_unstemmed |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_sort |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
author |
MOTTA,Ana Carolina Fragoso |
author_facet |
MOTTA,Ana Carolina Fragoso MACEDO,Leandro Dorigan de SANTOS,Gisele Guimarães GUERREIRO,Carlos Tostes FERRARI,Tatiane OLIVEIRA,Thais Feitosa Leitão de SANTOS,Paulo Sérgio da Silva OLIVEIRA-SANTOS,Christiano de RICZ,Hilton Marcos Alves XAVIER,Samuel Porfírio IANNETTA,Odilon |
author_role |
author |
author2 |
MACEDO,Leandro Dorigan de SANTOS,Gisele Guimarães GUERREIRO,Carlos Tostes FERRARI,Tatiane OLIVEIRA,Thais Feitosa Leitão de SANTOS,Paulo Sérgio da Silva OLIVEIRA-SANTOS,Christiano de RICZ,Hilton Marcos Alves XAVIER,Samuel Porfírio IANNETTA,Odilon |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
MOTTA,Ana Carolina Fragoso MACEDO,Leandro Dorigan de SANTOS,Gisele Guimarães GUERREIRO,Carlos Tostes FERRARI,Tatiane OLIVEIRA,Thais Feitosa Leitão de SANTOS,Paulo Sérgio da Silva OLIVEIRA-SANTOS,Christiano de RICZ,Hilton Marcos Alves XAVIER,Samuel Porfírio IANNETTA,Odilon |
dc.subject.por.fl_str_mv |
Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
topic |
Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
description |
Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107BOR-2015.vol29.0106 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.29 n.1 2015 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
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1750318324340752384 |