Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106 http://hdl.handle.net/11449/185705 |
Resumo: | Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ. |
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Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jawsBisphosphonate-Associated Osteonecrosis of the JawDental CareUltrasonographyBone DensityPatients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto, SP, BrazilHosp Clin, Div Dent & Oral Diag, Ribeirao Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dent Sch Bauru, Dept Stomatol, Bauru, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Gynecol & Obstet, Ribeirao Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, BrazilSociedade Brasileira De Pesquisa OdontologicaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Fragoso Motta, Ana CarolinaMacedo, Leandro Dorigan deSantos, Gisele Guimaraes [UNESP]Guerreiro, Carlos TostesFerrari, TatianeLeitao de Oliveira, Thais FeitosaSilva Santos, Paulo Sergio daOliveira-Santos, Christiano deAlves Ricz, Hilton MarcosXavier, Samuel PorfirioIannetta, Odilon2019-10-04T12:37:51Z2019-10-04T12:37:51Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015.1807-3107http://hdl.handle.net/11449/18570510.1590/1807-3107BOR-2015.vol29.0106S1806-83242015000100301WOS:000467431900039S1806-83242015000100301.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Researchinfo:eu-repo/semantics/openAccess2024-06-21T12:46:50Zoai:repositorio.unesp.br:11449/185705Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:25:30.104794Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
spellingShingle |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws Fragoso Motta, Ana Carolina Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
title_short |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_full |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_fullStr |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_full_unstemmed |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
title_sort |
Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws |
author |
Fragoso Motta, Ana Carolina |
author_facet |
Fragoso Motta, Ana Carolina Macedo, Leandro Dorigan de Santos, Gisele Guimaraes [UNESP] Guerreiro, Carlos Tostes Ferrari, Tatiane Leitao de Oliveira, Thais Feitosa Silva Santos, Paulo Sergio da Oliveira-Santos, Christiano de Alves Ricz, Hilton Marcos Xavier, Samuel Porfirio Iannetta, Odilon |
author_role |
author |
author2 |
Macedo, Leandro Dorigan de Santos, Gisele Guimaraes [UNESP] Guerreiro, Carlos Tostes Ferrari, Tatiane Leitao de Oliveira, Thais Feitosa Silva Santos, Paulo Sergio da Oliveira-Santos, Christiano de Alves Ricz, Hilton Marcos Xavier, Samuel Porfirio Iannetta, Odilon |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fragoso Motta, Ana Carolina Macedo, Leandro Dorigan de Santos, Gisele Guimaraes [UNESP] Guerreiro, Carlos Tostes Ferrari, Tatiane Leitao de Oliveira, Thais Feitosa Silva Santos, Paulo Sergio da Oliveira-Santos, Christiano de Alves Ricz, Hilton Marcos Xavier, Samuel Porfirio Iannetta, Odilon |
dc.subject.por.fl_str_mv |
Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
topic |
Bisphosphonate-Associated Osteonecrosis of the Jaw Dental Care Ultrasonography Bone Density |
description |
Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2019-10-04T12:37:51Z 2019-10-04T12:37:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106 Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015. 1807-3107 http://hdl.handle.net/11449/185705 10.1590/1807-3107BOR-2015.vol29.0106 S1806-83242015000100301 WOS:000467431900039 S1806-83242015000100301.pdf |
url |
http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106 http://hdl.handle.net/11449/185705 |
identifier_str_mv |
Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015. 1807-3107 10.1590/1807-3107BOR-2015.vol29.0106 S1806-83242015000100301 WOS:000467431900039 S1806-83242015000100301.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira De Pesquisa Odontologica |
publisher.none.fl_str_mv |
Sociedade Brasileira De Pesquisa Odontologica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128930511585280 |