Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws

Detalhes bibliográficos
Autor(a) principal: Fragoso Motta, Ana Carolina
Data de Publicação: 2015
Outros Autores: Macedo, Leandro Dorigan de, Santos, Gisele Guimaraes [UNESP], Guerreiro, Carlos Tostes, Ferrari, Tatiane, Leitao de Oliveira, Thais Feitosa, Silva Santos, Paulo Sergio da, Oliveira-Santos, Christiano de, Alves Ricz, Hilton Marcos, Xavier, Samuel Porfirio, Iannetta, Odilon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106
http://hdl.handle.net/11449/185705
Resumo: Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.
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spelling Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jawsBisphosphonate-Associated Osteonecrosis of the JawDental CareUltrasonographyBone DensityPatients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto, SP, BrazilHosp Clin, Div Dent & Oral Diag, Ribeirao Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dent Sch Bauru, Dept Stomatol, Bauru, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Gynecol & Obstet, Ribeirao Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, BrazilSociedade Brasileira De Pesquisa OdontologicaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Fragoso Motta, Ana CarolinaMacedo, Leandro Dorigan deSantos, Gisele Guimaraes [UNESP]Guerreiro, Carlos TostesFerrari, TatianeLeitao de Oliveira, Thais FeitosaSilva Santos, Paulo Sergio daOliveira-Santos, Christiano deAlves Ricz, Hilton MarcosXavier, Samuel PorfirioIannetta, Odilon2019-10-04T12:37:51Z2019-10-04T12:37:51Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015.1807-3107http://hdl.handle.net/11449/18570510.1590/1807-3107BOR-2015.vol29.0106S1806-83242015000100301WOS:000467431900039S1806-83242015000100301.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Researchinfo:eu-repo/semantics/openAccess2024-06-21T12:46:50Zoai:repositorio.unesp.br:11449/185705Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:25:30.104794Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
spellingShingle Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
Fragoso Motta, Ana Carolina
Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
title_short Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_full Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_fullStr Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_full_unstemmed Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
title_sort Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws
author Fragoso Motta, Ana Carolina
author_facet Fragoso Motta, Ana Carolina
Macedo, Leandro Dorigan de
Santos, Gisele Guimaraes [UNESP]
Guerreiro, Carlos Tostes
Ferrari, Tatiane
Leitao de Oliveira, Thais Feitosa
Silva Santos, Paulo Sergio da
Oliveira-Santos, Christiano de
Alves Ricz, Hilton Marcos
Xavier, Samuel Porfirio
Iannetta, Odilon
author_role author
author2 Macedo, Leandro Dorigan de
Santos, Gisele Guimaraes [UNESP]
Guerreiro, Carlos Tostes
Ferrari, Tatiane
Leitao de Oliveira, Thais Feitosa
Silva Santos, Paulo Sergio da
Oliveira-Santos, Christiano de
Alves Ricz, Hilton Marcos
Xavier, Samuel Porfirio
Iannetta, Odilon
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Fragoso Motta, Ana Carolina
Macedo, Leandro Dorigan de
Santos, Gisele Guimaraes [UNESP]
Guerreiro, Carlos Tostes
Ferrari, Tatiane
Leitao de Oliveira, Thais Feitosa
Silva Santos, Paulo Sergio da
Oliveira-Santos, Christiano de
Alves Ricz, Hilton Marcos
Xavier, Samuel Porfirio
Iannetta, Odilon
dc.subject.por.fl_str_mv Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
topic Bisphosphonate-Associated Osteonecrosis of the Jaw
Dental Care
Ultrasonography
Bone Density
description Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 +/- 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 +/- 0.12 vs. 0.70 +/- 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
2019-10-04T12:37:51Z
2019-10-04T12:37:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106
Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015.
1807-3107
http://hdl.handle.net/11449/185705
10.1590/1807-3107BOR-2015.vol29.0106
S1806-83242015000100301
WOS:000467431900039
S1806-83242015000100301.pdf
url http://dx.doi.org/10.1590/1807-3107BOR-2015.vol29.0106
http://hdl.handle.net/11449/185705
identifier_str_mv Brazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 29, n. 1, 9 p., 2015.
1807-3107
10.1590/1807-3107BOR-2015.vol29.0106
S1806-83242015000100301
WOS:000467431900039
S1806-83242015000100301.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Oral Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira De Pesquisa Odontologica
publisher.none.fl_str_mv Sociedade Brasileira De Pesquisa Odontologica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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