Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100251 |
Resumo: | Abstract The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on patients. Two hundred subjects were evaluated. A total of 75 subjects complied with the criteria. The participants were divided into two groups: a) Healthy pulp (subjects [n = 35] having posterior teeth with clinically normal pulp tissue), and b) Irreversible pulpitis (subjects [n = 40] having posterior teeth with irreversible pulpitis). All participants were evaluated using the following variables: a) medical and dental history, b) pulp sensitivity tests, c) expression of CGRP by the enzyme-linked immunosorbent assay (ELISA), and d) expression levels of mRNA CGRP and mRNA CGRP receptor genes. We determined that the responses of the cold test between 4 and ≥12 s presented a higher average of the expression of CGRP in the group having irreversible pulpitis (p = 0.0001). When we compared the groups with the value of the electrical impulse, we found statistically significant differences (p = 0.0001), observing positive responses to the test with electrical impulses of 7 to 10, with an average of 72.15 ng/mL of CGRP in the irreversible pulpitis group. High values of CGRP expression were observed in that group in the responses of pulp sensitivity. |
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Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitisCalcitonin Gene-Related PeptideDental pulp testAbstract The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on patients. Two hundred subjects were evaluated. A total of 75 subjects complied with the criteria. The participants were divided into two groups: a) Healthy pulp (subjects [n = 35] having posterior teeth with clinically normal pulp tissue), and b) Irreversible pulpitis (subjects [n = 40] having posterior teeth with irreversible pulpitis). All participants were evaluated using the following variables: a) medical and dental history, b) pulp sensitivity tests, c) expression of CGRP by the enzyme-linked immunosorbent assay (ELISA), and d) expression levels of mRNA CGRP and mRNA CGRP receptor genes. We determined that the responses of the cold test between 4 and ≥12 s presented a higher average of the expression of CGRP in the group having irreversible pulpitis (p = 0.0001). When we compared the groups with the value of the electrical impulse, we found statistically significant differences (p = 0.0001), observing positive responses to the test with electrical impulses of 7 to 10, with an average of 72.15 ng/mL of CGRP in the irreversible pulpitis group. High values of CGRP expression were observed in that group in the responses of pulp sensitivity.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100251Brazilian Oral Research v.33 2019reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2019.vol33.0077info:eu-repo/semantics/openAccessCASTILLO-SILVA,Brenda EréndidaMARTÍNEZ-JIMÉNEZ,VerónicaMARTÍNEZ- CASTAÑÓN,Gabriel AlejandroMEDINA-SOLÍS,Carlo EduardoAGUIRRE-LÓPEZ,Eva ConcepciónCASTILLO-HERNÁNDEZ,Jesús RamónNIÑO-MARTÍNEZ,NereydaPATIÑO-MARÍN,Nuriaeng2019-09-04T00:00:00Zoai:scielo:S1806-83242019000100251Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2019-09-04T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
title |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
spellingShingle |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis CASTILLO-SILVA,Brenda Eréndida Calcitonin Gene-Related Peptide Dental pulp test |
title_short |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
title_full |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
title_fullStr |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
title_full_unstemmed |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
title_sort |
Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis |
author |
CASTILLO-SILVA,Brenda Eréndida |
author_facet |
CASTILLO-SILVA,Brenda Eréndida MARTÍNEZ-JIMÉNEZ,Verónica MARTÍNEZ- CASTAÑÓN,Gabriel Alejandro MEDINA-SOLÍS,Carlo Eduardo AGUIRRE-LÓPEZ,Eva Concepción CASTILLO-HERNÁNDEZ,Jesús Ramón NIÑO-MARTÍNEZ,Nereyda PATIÑO-MARÍN,Nuria |
author_role |
author |
author2 |
MARTÍNEZ-JIMÉNEZ,Verónica MARTÍNEZ- CASTAÑÓN,Gabriel Alejandro MEDINA-SOLÍS,Carlo Eduardo AGUIRRE-LÓPEZ,Eva Concepción CASTILLO-HERNÁNDEZ,Jesús Ramón NIÑO-MARTÍNEZ,Nereyda PATIÑO-MARÍN,Nuria |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
CASTILLO-SILVA,Brenda Eréndida MARTÍNEZ-JIMÉNEZ,Verónica MARTÍNEZ- CASTAÑÓN,Gabriel Alejandro MEDINA-SOLÍS,Carlo Eduardo AGUIRRE-LÓPEZ,Eva Concepción CASTILLO-HERNÁNDEZ,Jesús Ramón NIÑO-MARTÍNEZ,Nereyda PATIÑO-MARÍN,Nuria |
dc.subject.por.fl_str_mv |
Calcitonin Gene-Related Peptide Dental pulp test |
topic |
Calcitonin Gene-Related Peptide Dental pulp test |
description |
Abstract The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on patients. Two hundred subjects were evaluated. A total of 75 subjects complied with the criteria. The participants were divided into two groups: a) Healthy pulp (subjects [n = 35] having posterior teeth with clinically normal pulp tissue), and b) Irreversible pulpitis (subjects [n = 40] having posterior teeth with irreversible pulpitis). All participants were evaluated using the following variables: a) medical and dental history, b) pulp sensitivity tests, c) expression of CGRP by the enzyme-linked immunosorbent assay (ELISA), and d) expression levels of mRNA CGRP and mRNA CGRP receptor genes. We determined that the responses of the cold test between 4 and ≥12 s presented a higher average of the expression of CGRP in the group having irreversible pulpitis (p = 0.0001). When we compared the groups with the value of the electrical impulse, we found statistically significant differences (p = 0.0001), observing positive responses to the test with electrical impulses of 7 to 10, with an average of 72.15 ng/mL of CGRP in the irreversible pulpitis group. High values of CGRP expression were observed in that group in the responses of pulp sensitivity. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100251 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100251 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2019.vol33.0077 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.33 2019 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
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1750318326580510720 |